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The effects of lidocaine on the fetal circulatory responses to asphyxia were evaluated in chronically instrumented pregnant sheep. Twenty-six preparations were studied. Animals were assigned to one of three groups. The animals in group I (N = 10) did not have umbilical cord occluders placed. Lidocaine at 0.1 mg X kg-1 X min-1 was infused to the mother for 180 min. The animals in group II (N = 11) had an umbilical cord occluder, which was inflated to induce fetal asphyxia (PaO2 15 mmHg) for 90 min. Occlusion was then maintained for an additional 180 min while lidocaine at 0.1 mg X kg-1 X min-1 was infused. The animals in group III (N = 5) also had an umbilical cord occluder inflated for 90 min. While occlusion was maintained for an additional 180 min, saline was infused, in place of lidocaine. The infusion rate of lidocaine of 0.1 mg X kg-1 X min-1 over 180 min resulted in a steady-state arterial lidocaine blood concentration in the mother of approximately 2.15 micrograms/ml. Fetal circulatory responses to asphyxia were evaluated before and after maternal infusion of lidocaine or normal saline. Measurements included heart rate, blood pressure, arterial pH, and blood gases. Cardiac output and organ blood flow were determined using the radio-labelled microsphere technique. In general, arterial and tissue lidocaine concentrations in asphyxiated fetuses were higher than those in the nonasphyxiated ones, the differences being significant in the brain, heart, liver, and adrenal glands.(ABSTRACT TRUNCATED AT 250 WORDS)
H O Morishima, and
A C Santos, and
H Pedersen, and
M Finster, and
A Tsuji, and
H Hiraoka, and
G R Arthur, and
B G Covino
February 1976,
Anesthesiology,
H O Morishima, and
A C Santos, and
H Pedersen, and
M Finster, and
A Tsuji, and
H Hiraoka, and
G R Arthur, and
B G Covino
August 1967,
Circulation research,
H O Morishima, and
A C Santos, and
H Pedersen, and
M Finster, and
A Tsuji, and
H Hiraoka, and
G R Arthur, and
B G Covino
May 1989,
American journal of obstetrics and gynecology,
H O Morishima, and
A C Santos, and
H Pedersen, and
M Finster, and
A Tsuji, and
H Hiraoka, and
G R Arthur, and
B G Covino
July 1981,
The American journal of physiology,
H O Morishima, and
A C Santos, and
H Pedersen, and
M Finster, and
A Tsuji, and
H Hiraoka, and
G R Arthur, and
B G Covino
June 1979,
Clinical immunology and immunopathology,
H O Morishima, and
A C Santos, and
H Pedersen, and
M Finster, and
A Tsuji, and
H Hiraoka, and
G R Arthur, and
B G Covino
August 1990,
Journal of developmental physiology,
H O Morishima, and
A C Santos, and
H Pedersen, and
M Finster, and
A Tsuji, and
H Hiraoka, and
G R Arthur, and
B G Covino
July 1975,
American journal of obstetrics and gynecology,
H O Morishima, and
A C Santos, and
H Pedersen, and
M Finster, and
A Tsuji, and
H Hiraoka, and
G R Arthur, and
B G Covino
September 1966,
Acta paediatrica Scandinavica,
H O Morishima, and
A C Santos, and
H Pedersen, and
M Finster, and
A Tsuji, and
H Hiraoka, and
G R Arthur, and
B G Covino
May 1987,
Canadian journal of anaesthesia = Journal canadien d'anesthesie,
H O Morishima, and
A C Santos, and
H Pedersen, and
M Finster, and
A Tsuji, and
H Hiraoka, and
G R Arthur, and
B G Covino
January 1972,
American journal of obstetrics and gynecology,
