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We studied the effects of almitrine, acetazolamide, and placebo on the hypoxic ventilatory response (HVR), sleep periodic breathing, and arterial oxygen saturation (SaO2) in 4 healthy climbers. In a laboratory on Denali (Mt. McKinley) at 4,400 m (PB = 440 mm Hg), we used a double-blind, randomized, three-way crossover design. The HVR was measured during the waking state. Periodic breathing and SAO2% were measured during 3-h sleep studies. Almitrine and acetazolamide both increased SaO2% during sleep, although almitrine increased periodic breathing, whereas acetazolamide decreased periodic breathing. The HVR (delta VE/delta SaO2%) was doubled with almitrine (p less than 0.05), but unchanged with acetazolamide. The HVR was positively related to periodic breathing (p less than 0.05). We conclude that periodic breathing during sleep at high altitude is related to the hypoxic ventilatory response, and that acetazolamide is a superior agent to almitrine for ameliorating periodic breathing.
P H Hackett, and
R C Roach, and
G L Harrison, and
R B Schoene, and
W J Mills
January 2004,
The European respiratory journal,
P H Hackett, and
R C Roach, and
G L Harrison, and
R B Schoene, and
W J Mills
January 2015,
Chest,
P H Hackett, and
R C Roach, and
G L Harrison, and
R B Schoene, and
W J Mills
December 2002,
IMA journal of mathematics applied in medicine and biology,
P H Hackett, and
R C Roach, and
G L Harrison, and
R B Schoene, and
W J Mills
September 2013,
Respiratory physiology & neurobiology,
P H Hackett, and
R C Roach, and
G L Harrison, and
R B Schoene, and
W J Mills
January 1999,
Sleep & breathing = Schlaf & Atmung,
P H Hackett, and
R C Roach, and
G L Harrison, and
R B Schoene, and
W J Mills
January 2015,
Sleep disorders,
P H Hackett, and
R C Roach, and
G L Harrison, and
R B Schoene, and
W J Mills
March 2016,
Sleep & breathing = Schlaf & Atmung,
P H Hackett, and
R C Roach, and
G L Harrison, and
R B Schoene, and
W J Mills
December 2012,
High altitude medicine & biology,
P H Hackett, and
R C Roach, and
G L Harrison, and
R B Schoene, and
W J Mills
March 1990,
Aviation, space, and environmental medicine,
P H Hackett, and
R C Roach, and
G L Harrison, and
R B Schoene, and
W J Mills
June 2013,
Journal of sleep research,
