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The effect of the individual enantiomers of warfarin at steady state (1 mg daily) was investigated in five healthy volunteers. Both enantiomers produced a significant increase in prothrombin time, but the increase with S warfarin (1.8 +/- 0.8 s, mean +/- s.d.) was greater than with R warfarin (1.0 +/- 0.3 s), despite lower steady state plasma concentrations of S warfarin, due to its more rapid clearance. Following the administration of vitamin K1, the maximum plasma concentration and area under the plasma concentration time curve values for the metabolite vitamin K1 2,3-epoxide were greater after S warfarin than after R warfarin. The greater anticoagulant potency of S warfarin is reflected by a greater degree of inhibition of vitamin K1 epoxide reductase.
I A Choonara, and
B P Haynes, and
S Cholerton, and
A M Breckenridge, and
B K Park
December 1974,
Biochemical pharmacology,
I A Choonara, and
B P Haynes, and
S Cholerton, and
A M Breckenridge, and
B K Park
July 1979,
The Journal of pharmacy and pharmacology,
I A Choonara, and
B P Haynes, and
S Cholerton, and
A M Breckenridge, and
B K Park
November 1981,
Biochemical pharmacology,
I A Choonara, and
B P Haynes, and
S Cholerton, and
A M Breckenridge, and
B K Park
October 1978,
Lancet (London, England),
I A Choonara, and
B P Haynes, and
S Cholerton, and
A M Breckenridge, and
B K Park
February 1979,
Lancet (London, England),
I A Choonara, and
B P Haynes, and
S Cholerton, and
A M Breckenridge, and
B K Park
June 1979,
Naunyn-Schmiedeberg's archives of pharmacology,
I A Choonara, and
B P Haynes, and
S Cholerton, and
A M Breckenridge, and
B K Park
January 1976,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
I A Choonara, and
B P Haynes, and
S Cholerton, and
A M Breckenridge, and
B K Park
May 1974,
Molecular pharmacology,
I A Choonara, and
B P Haynes, and
S Cholerton, and
A M Breckenridge, and
B K Park
January 1996,
The Annals of pharmacotherapy,
I A Choonara, and
B P Haynes, and
S Cholerton, and
A M Breckenridge, and
B K Park
June 1977,
Clinical science and molecular medicine,
