-transparent.png){kind=logo}
Time course of the effects of morphine on the hypothalamic content of LHRH in both nontolerant and morphine-tolerant male rats was investigated in relation to the temporal changes of serum testosterone and LH levels. The hypothalamic LHRH content of the nontolerant rats was increased 8 hr after the administration of morphine (100 mg/kg) when serum testosterone levels were depressed. The LHRH content of the tolerant rats was decreased during withdrawal of morphine for 48 hr when the lowered serum testosterone and LH levels had returned to within the control levels. Although the hypothalamic LHRH content does not necessarily reflect the release of LHRH, these results are in favour of the hypothesis that the release of hypothalamic LHRH is inhibited by the administration of morphine and is restored by the withdrawal of the narcotic.
T Muraki, and
Y Tokunaga, and
S Matsumoto, and
T Makino
December 1981,
Neuroendocrinology,
T Muraki, and
Y Tokunaga, and
S Matsumoto, and
T Makino
October 1979,
The Journal of pharmacology and experimental therapeutics,
T Muraki, and
Y Tokunaga, and
S Matsumoto, and
T Makino
July 1977,
Endokrinologie,
T Muraki, and
Y Tokunaga, and
S Matsumoto, and
T Makino
February 1982,
International journal of andrology,
T Muraki, and
Y Tokunaga, and
S Matsumoto, and
T Makino
April 2004,
Inhalation toxicology,
T Muraki, and
Y Tokunaga, and
S Matsumoto, and
T Makino
February 2001,
Biological & pharmaceutical bulletin,
T Muraki, and
Y Tokunaga, and
S Matsumoto, and
T Makino
September 1985,
Neuroendocrinology,
T Muraki, and
Y Tokunaga, and
S Matsumoto, and
T Makino
January 1976,
Neuroendocrinology,
T Muraki, and
Y Tokunaga, and
S Matsumoto, and
T Makino
November 1972,
The Journal of endocrinology,
T Muraki, and
Y Tokunaga, and
S Matsumoto, and
T Makino
November 1989,
Pharmacology, biochemistry, and behavior,
