-transparent.png){kind=logo}
A monoclonal antibody to carcinoembryonic antigen (CEA) (F023C5), belonging to IgG1 class, was obtained by cell fusion technique. Preliminary screening on different tissues was performed with immunoperoxidase staining, which showed good specificity of the antibody for gastric and colorectal carcinomas. F(ab')2 fragments were subsequently prepared and labeled with 131I and 111In. After immunoreactivity check the radiopharmaceuticals were injected intravenously. Sixteen patients with 22 primary or secondary localizations of colorectal carcinoma were studied following the recommendations of the ethical Committee of the Istituto Nazionale Tumori, Milan, Italy. Serial scans were performed after injection of the two radioactive reagents. In vivo pharmacokinetics of the compound was studied. Radioactivity level in surgical specimens was measured, and immunostaining was performed. All tumors were found to express the antigen. Eleven out of 12 tumor localizations of the gastrointestinal tract and three out of ten liver metastases were imaged. Specificity of tumor uptake was assessed by simultaneous injection of an irrelevant antibody.
G Buraggi, and
L Callegaro, and
A Turrin, and
L Gennari, and
E Bombardieri, and
G Mariani, and
G Deleide, and
M Dovis, and
M Gasparini, and
R Doci
January 1987,
Rays,
G Buraggi, and
L Callegaro, and
A Turrin, and
L Gennari, and
E Bombardieri, and
G Mariani, and
G Deleide, and
M Dovis, and
M Gasparini, and
R Doci
August 1988,
Nuclear medicine communications,
G Buraggi, and
L Callegaro, and
A Turrin, and
L Gennari, and
E Bombardieri, and
G Mariani, and
G Deleide, and
M Dovis, and
M Gasparini, and
R Doci
March 1992,
Nihon Geka Gakkai zasshi,
G Buraggi, and
L Callegaro, and
A Turrin, and
L Gennari, and
E Bombardieri, and
G Mariani, and
G Deleide, and
M Dovis, and
M Gasparini, and
R Doci
June 1993,
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
G Buraggi, and
L Callegaro, and
A Turrin, and
L Gennari, and
E Bombardieri, and
G Mariani, and
G Deleide, and
M Dovis, and
M Gasparini, and
R Doci
January 1994,
European journal of cancer (Oxford, England : 1990),
G Buraggi, and
L Callegaro, and
A Turrin, and
L Gennari, and
E Bombardieri, and
G Mariani, and
G Deleide, and
M Dovis, and
M Gasparini, and
R Doci
January 1991,
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology,
G Buraggi, and
L Callegaro, and
A Turrin, and
L Gennari, and
E Bombardieri, and
G Mariani, and
G Deleide, and
M Dovis, and
M Gasparini, and
R Doci
January 1986,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
G Buraggi, and
L Callegaro, and
A Turrin, and
L Gennari, and
E Bombardieri, and
G Mariani, and
G Deleide, and
M Dovis, and
M Gasparini, and
R Doci
May 1995,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
G Buraggi, and
L Callegaro, and
A Turrin, and
L Gennari, and
E Bombardieri, and
G Mariani, and
G Deleide, and
M Dovis, and
M Gasparini, and
R Doci
January 1987,
European journal of nuclear medicine,
G Buraggi, and
L Callegaro, and
A Turrin, and
L Gennari, and
E Bombardieri, and
G Mariani, and
G Deleide, and
M Dovis, and
M Gasparini, and
R Doci
November 1983,
Radiology,
