[Classic hairy cell leukemia with MAP2K1 mutation: a case report].
2022
C Wei, and
H Cai, and
X Y Jiang, and
X Wang, and
D B Zhou, and
J L Zhuang
Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
UI
MeSH Term
Description
Entries
D007943
Leukemia, Hairy Cell
A neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukemia; it is characterized by an insidious onset, splenomegaly, anemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of "hairy" or "flagellated" cells in the blood and bone marrow.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Mutations
D006801
Humans
Members of the species Homo sapiens.
Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D048369
MAP Kinase Kinase 1
An abundant 43-kDa mitogen-activated protein kinase kinase subtype with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 1 and MITOGEN-ACTIVATED PROTEIN KINASE 3.
MAP2K1 Protein,MAPK Kinase 1,MEK-1 Protein Kinase,MEK1 Protein Kinase,MKK-1 Protein Kinase,MKK1 Protein Kinase,Mitogen-Activated Protein Kinase Kinase 1,MEK 1 Protein Kinase,MKK 1 Protein Kinase,Mitogen Activated Protein Kinase Kinase 1
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C Wei, and
H Cai, and
X Y Jiang, and
X Wang, and
D B Zhou, and
J L Zhuang