-transparent.png){kind=logo}
Chronic liver diseases may be associated with the appearance of antinuclear antibodies. To further analyze the relationship between connective tissue and liver diseases the sera of 88 patients with chronic liver disorders were examined for the presence of common lupus anti-DNA idiotypes (16/6-id, 134-id, and 32/15-id), using an enzyme-linked immunosorbent assay. The 16/6-id was found in 58 (65.9%), the 134-id in 43 (48.9%), and the 32/15-id in 13 (14.8%) of the patients' sera. Distinct diagnostic groups displayed different lupus anti-DNA idiotype profiles. Patients with primary biliary cirrhosis (PBC) and chronic active hepatitis (CAH) had mainly the 16/6 idiotype, while in alcoholic (AC) and in cryptogenic cirrhosis (CC) the 16/6-id and 134-id were the main idiotypes recorded. There was considerable correlation among the different anti-DNA idiotypes but not between any of these idiotypes and an unrelated common anti-HBsAg idiotype. The occurrence of the various idiotypes was not found to be correlated with increased serum immunoglobulin levels. It can be concluded that the similarities between chronic liver diseases and connective tissue diseases are extended also to the presence of specific common anti-DNA antibody idiotypes.
F Konikoff, and
D A Isenberg, and
O Kooperman, and
R C Kennedy, and
J Rauch, and
E Theodor, and
Y Shoenfeld
March 1988,
Immunology letters,
F Konikoff, and
D A Isenberg, and
O Kooperman, and
R C Kennedy, and
J Rauch, and
E Theodor, and
Y Shoenfeld
August 1984,
Lancet (London, England),
F Konikoff, and
D A Isenberg, and
O Kooperman, and
R C Kennedy, and
J Rauch, and
E Theodor, and
Y Shoenfeld
December 1994,
Harefuah,
F Konikoff, and
D A Isenberg, and
O Kooperman, and
R C Kennedy, and
J Rauch, and
E Theodor, and
Y Shoenfeld
January 1990,
Japanese journal of medicine,
F Konikoff, and
D A Isenberg, and
O Kooperman, and
R C Kennedy, and
J Rauch, and
E Theodor, and
Y Shoenfeld
May 1988,
Journal of immunology (Baltimore, Md. : 1950),
F Konikoff, and
D A Isenberg, and
O Kooperman, and
R C Kennedy, and
J Rauch, and
E Theodor, and
Y Shoenfeld
October 1984,
Lancet (London, England),
F Konikoff, and
D A Isenberg, and
O Kooperman, and
R C Kennedy, and
J Rauch, and
E Theodor, and
Y Shoenfeld
January 1987,
Cellular immunology,
F Konikoff, and
D A Isenberg, and
O Kooperman, and
R C Kennedy, and
J Rauch, and
E Theodor, and
Y Shoenfeld
January 1986,
Medicine,
F Konikoff, and
D A Isenberg, and
O Kooperman, and
R C Kennedy, and
J Rauch, and
E Theodor, and
Y Shoenfeld
May 1990,
The Journal of clinical investigation,
F Konikoff, and
D A Isenberg, and
O Kooperman, and
R C Kennedy, and
J Rauch, and
E Theodor, and
Y Shoenfeld
July 1985,
The Journal of clinical investigation,
