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The influence on tracheobronchial clearance of ambroxol, a metabolite of bromhexine, was investigated by measuring the lung retention of inhaled 6 micron monodisperse Teflon particles labelled with 99mTc. Fourteen subjects with simple chronic bronchitis, who belonged to a "responder" group in an earlier study on the subjective effects of ambroxol, were examined using a double-blind cross-over design comparing 120 mg ambroxol daily and placebo. On commencing the study and after each 2-week treatment period, the subjects were examined for mucociliary clearance and clearance by voluntary coughing. Treatment did not influence mucociliary clearance or clearance by cough. There is still a possibility that phlegm loosening by cough is enhanced in situations with more hypersecretion.
C H Ericsson, and
J Juhász, and
B Mossberg, and
K Philipson, and
M Svartengren, and
P Camner
October 1980,
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C H Ericsson, and
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K Philipson, and
M Svartengren, and
P Camner
January 1995,
Respiration; international review of thoracic diseases,
C H Ericsson, and
J Juhász, and
B Mossberg, and
K Philipson, and
M Svartengren, and
P Camner
January 1980,
European journal of respiratory diseases. Supplement,
C H Ericsson, and
J Juhász, and
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K Philipson, and
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P Camner
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Respiration; international review of thoracic diseases,
C H Ericsson, and
J Juhász, and
B Mossberg, and
K Philipson, and
M Svartengren, and
P Camner
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European journal of respiratory diseases. Supplement,
C H Ericsson, and
J Juhász, and
B Mossberg, and
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M Svartengren, and
P Camner
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C H Ericsson, and
J Juhász, and
B Mossberg, and
K Philipson, and
M Svartengren, and
P Camner
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C H Ericsson, and
J Juhász, and
B Mossberg, and
K Philipson, and
M Svartengren, and
P Camner
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Thorax,
C H Ericsson, and
J Juhász, and
B Mossberg, and
K Philipson, and
M Svartengren, and
P Camner
January 1989,
Archivio Monaldi per le malattie del torace,
C H Ericsson, and
J Juhász, and
B Mossberg, and
K Philipson, and
M Svartengren, and
P Camner
October 1987,
Chest,
