Apple polyphenols improve intestinal barrier function by enhancing antioxidant capacity and suppressing inflammation in weaning piglets. 2022

Zhongyang Guo, and Xiaoling Chen, and Zhiqing Huang, and Daiwen Chen, and Jie Yu, and Hui Yan, and Hong Chen, and Jun He, and Ping Zheng, and Yuheng Luo, and Bing Yu
Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, China.

This study aimed to examine the effects of apple polyphenols (APPs) on antioxidant capacity, immune and inflammatory response, and barrier function in weaning piglets. Results showed that APPs improved jejunal barrier function by increasing the villus height, villus height/crypt depth, the mRNA levels of occludin, mucin-1, and mucin-4 and up-regulating the protein expression of occluding (P < 0.05). As for antioxidant capacity, APPs increased the activities of total superoxide dismutase and glutathione peroxidase and total antioxidant capacity level in jejunum (P < 0.05). Besides, APPs up-regulated the protein expressions of NAD(P)H quinone dehydrogenase 1 (NQO1), heme oxygenase-1 (HO-1), and nuclear-related factor 2 (NRF2) and down-regulated the protein expression of kelch-like ECH-associated protein 1 (Keap1). As regard to immune and inflammatory response, APPs increased the immunoglobulin A content in serum and decreased the mRNA levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, toll-like receptor 4 (TLR4), nuclear factor-κB (NF-κB), and IL-8 in jejunum (P < 0.05). Overall, dietary APPs supplementation improves the jejunal barrier function by enhancing antioxidant capacity and suppressing the mRNA expression related to inflammation, which may be related to the NRF2 signal and TLR4/NF-κB signal.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D000072019 Kelch-Like ECH-Associated Protein 1 An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS. KEAP-1 Protein,KEAP1 Protein,KEAP 1 Protein,Kelch Like ECH Associated Protein 1
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000975 Antioxidants Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. Anti-Oxidant,Antioxidant,Antioxidant Activity,Endogenous Antioxidant,Endogenous Antioxidants,Anti-Oxidant Effect,Anti-Oxidant Effects,Anti-Oxidants,Antioxidant Effect,Antioxidant Effects,Activity, Antioxidant,Anti Oxidant,Anti Oxidant Effect,Anti Oxidant Effects,Anti Oxidants,Antioxidant, Endogenous,Antioxidants, Endogenous
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D013553 Swine Diseases Diseases of domestic swine and of the wild boar of the genus Sus. Disease, Swine,Diseases, Swine,Swine Disease
D014886 Weaning Permanent deprivation of breast milk and commencement of nourishment with other food. (From Stedman, 25th ed) Weanings
D016328 NF-kappa B Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA. Immunoglobulin Enhancer-Binding Protein,NF-kappa B Complex,Nuclear Factor kappa B,Transcription Factor NF-kB,kappa B Enhancer Binding Protein,Ig-EBP-1,NF-kB,NF-kappaB,Nuclear Factor-Kappab,Complex, NF-kappa B,Enhancer-Binding Protein, Immunoglobulin,Factor NF-kB, Transcription,Factor-Kappab, Nuclear,Ig EBP 1,Immunoglobulin Enhancer Binding Protein,NF kB,NF kappa B Complex,NF kappaB,NF-kB, Transcription Factor,Nuclear Factor Kappab,Transcription Factor NF kB
D051197 Toll-Like Receptor 4 A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA. TLR4 Receptor,Toll-4 Receptor,Receptor, TLR4,Toll 4 Receptor,Toll Like Receptor 4

Related Publications

Zhongyang Guo, and Xiaoling Chen, and Zhiqing Huang, and Daiwen Chen, and Jie Yu, and Hui Yan, and Hong Chen, and Jun He, and Ping Zheng, and Yuheng Luo, and Bing Yu
June 2022, Journal of agricultural and food chemistry,
Zhongyang Guo, and Xiaoling Chen, and Zhiqing Huang, and Daiwen Chen, and Jie Yu, and Hui Yan, and Hong Chen, and Jun He, and Ping Zheng, and Yuheng Luo, and Bing Yu
April 2018, Journal of animal science,
Zhongyang Guo, and Xiaoling Chen, and Zhiqing Huang, and Daiwen Chen, and Jie Yu, and Hui Yan, and Hong Chen, and Jun He, and Ping Zheng, and Yuheng Luo, and Bing Yu
January 2024, Frontiers in immunology,
Zhongyang Guo, and Xiaoling Chen, and Zhiqing Huang, and Daiwen Chen, and Jie Yu, and Hui Yan, and Hong Chen, and Jun He, and Ping Zheng, and Yuheng Luo, and Bing Yu
April 2022, Animal biotechnology,
Zhongyang Guo, and Xiaoling Chen, and Zhiqing Huang, and Daiwen Chen, and Jie Yu, and Hui Yan, and Hong Chen, and Jun He, and Ping Zheng, and Yuheng Luo, and Bing Yu
September 2019, Journal of animal physiology and animal nutrition,
Zhongyang Guo, and Xiaoling Chen, and Zhiqing Huang, and Daiwen Chen, and Jie Yu, and Hui Yan, and Hong Chen, and Jun He, and Ping Zheng, and Yuheng Luo, and Bing Yu
November 2022, Applied and environmental microbiology,
Zhongyang Guo, and Xiaoling Chen, and Zhiqing Huang, and Daiwen Chen, and Jie Yu, and Hui Yan, and Hong Chen, and Jun He, and Ping Zheng, and Yuheng Luo, and Bing Yu
September 2018, The Journal of nutritional biochemistry,
Zhongyang Guo, and Xiaoling Chen, and Zhiqing Huang, and Daiwen Chen, and Jie Yu, and Hui Yan, and Hong Chen, and Jun He, and Ping Zheng, and Yuheng Luo, and Bing Yu
January 2013, Communications in agricultural and applied biological sciences,
Zhongyang Guo, and Xiaoling Chen, and Zhiqing Huang, and Daiwen Chen, and Jie Yu, and Hui Yan, and Hong Chen, and Jun He, and Ping Zheng, and Yuheng Luo, and Bing Yu
April 2021, Animal biotechnology,
Zhongyang Guo, and Xiaoling Chen, and Zhiqing Huang, and Daiwen Chen, and Jie Yu, and Hui Yan, and Hong Chen, and Jun He, and Ping Zheng, and Yuheng Luo, and Bing Yu
January 2020, Ecotoxicology and environmental safety,
Copied contents to your clipboard!