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Current Perspective on Residual Knowledge Gaps in the Assessment of Transporter-Mediated Drug Interactions. 2022

Xinning Yang, and Kellie Reynolds, and Rajanikanth Madabushi, and Shiew-Mei Huang
Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.

Assessment of transporter-mediated drug-drug interaction (DDI) is integral to drug development. A risk-based approach leveraging in vitro, in vivo, and in silico information is used to evaluate the DDI liability of drugs and inform the instructions of use. While tremendous advances have been made in recent decades, there are knowledge gaps warranting further research. Herein, we focus on select areas to advance assessment of DDI potential for drugs as substrates, inhibitors, or inducers of certain transporters.

UI MeSH Term Description Entries
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000076722 Drug Development The entire process of bringing a new drug to the market. It includes both preclinical and clinical testing, and regulatory approval. Computational Prediction of Drug-Target Interactions,Drug Target Prediction,Medication Development,Pharmaceutical Development,Development, Drug,Development, Medication,Development, Pharmaceutical,Drug Target Predictions,Prediction, Drug Target,Target Prediction, Drug
D026901 Membrane Transport Proteins Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS. Biological Pump,Membrane Transport Protein,Membrane Transporter,Membrane Transporters,Metabolic Pump,Permease,Biological Pumps,Metabolic Pumps,Permeases,Pump, Biologic,Pump, Biological,Pump, Metabolic,Pumps, Biological,Pumps, Metabolic,Biologic Pump,Protein, Membrane Transport,Transport Protein, Membrane,Transport Proteins, Membrane,Transporter, Membrane,Transporters, Membrane
D065693 Cytochrome P-450 Enzyme Inducers Drugs and compounds that induce the synthesis of CYTOCHROME P-450 ENZYMES. Cytochrome P-450 Inducers,Cytochrome P-450 Monooxygenase Inducers,Cytochrome P-450 Oxygenase Inducers,Cytochrome P-450-Dependent Monooxygenase Inducers,P-450 Enzyme Inducers,Cytochrome P 450 Dependent Monooxygenase Inducers,Cytochrome P 450 Enzyme Inducers,Cytochrome P 450 Inducers,Cytochrome P 450 Monooxygenase Inducers,Cytochrome P 450 Oxygenase Inducers,Enzyme Inducers, P-450,Inducers, P-450 Enzyme,P 450 Enzyme Inducers

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