Biomaterial Database

Role of ocular surface neurobiology in neuronal-mediated inflammation in dry eye disease. 2022

Kofi Asiedu

School of Optometry & Vision Science, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia. Electronic address: kasiedu60@yahoo.com.

Inflammation is the consequence of dry eye disease regardless of its etiology. Several injurious or harmless processes to the ocular surface neurons promote ocular surface neurogenic inflammation, leading to the vicious cycle of dry eye disease. These processes include the regular release of neuromediators during the conduction of ocular surface sensations, hyperosmolarity-induced ocular surface neuronal damage, neuro-regenerative activities, and neuronal-mediated dendritic cell activities. Neurogenic inflammation appears to be the main culprit, instigating the self-perpetuating inflammation observed in patients with dry eye disease.

UI	MeSH Term	Description	Entries
D007249	Inflammation	A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D009446	Neurobiology	The study of the structure, growth, activities, and functions of NEURONS and the NERVOUS SYSTEM.	Cellular Neurobiology,Molecular Neurobiology,Neurobiology, Cellular,Neurobiology, Molecular
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015352	Dry Eye Syndromes	Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.	Dry Eye,Dry Eye Disease,Evaporative Dry Eye,Evaporative Dry Eye Disease,Evaporative Dry Eye Syndrome,Dry Eye Diseases,Dry Eye Syndrome,Dry Eye, Evaporative,Dry Eyes,Evaporative Dry Eyes
D020078	Neurogenic Inflammation	Inflammation caused by an injurious stimulus of peripheral neurons and resulting in release of neuropeptides which affect vascular permeability and help initiate proinflammatory and immune reactions at the site of injury.	Inflammation, Neurogenic,Inflammations, Neurogenic,Neurogenic Inflammations