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We studied the synergistic enhancement effects of two chemicals which are different in their mechanism of action on DNA in cells. The test chemicals used were ethyl methanesulfonate (EMS) as an alkylating agent and cytosine arabinoside (Ara-C) as an analogue of cytidine. For determination of mutagenesis we measured the induction of resistance to 6-thioguanine (6-TG) in Chinese hamster V79 cells. EMS had a strong mutagenic effect on V79 cells, but for Ara-C the results were less clear. In this study, Ara-C had no detectable effect in inducing mutation up to a concentration of 5 X 10(-4) M. The mutation frequency of combined treatment with EMS and Ara-C was significantly higher than that obtained with EMS alone. These results indicate that Ara-C had an enhancing effect on mutations induced by EMS.
K Tachi-Shinkawa, and
Y Kuroda, and
K Morimoto, and
A Koizumi
August 1978,
Mutation research,
K Tachi-Shinkawa, and
Y Kuroda, and
K Morimoto, and
A Koizumi
April 1992,
Mutation research,
K Tachi-Shinkawa, and
Y Kuroda, and
K Morimoto, and
A Koizumi
August 1982,
Mutation research,
K Tachi-Shinkawa, and
Y Kuroda, and
K Morimoto, and
A Koizumi
February 1983,
Mutation research,
K Tachi-Shinkawa, and
Y Kuroda, and
K Morimoto, and
A Koizumi
January 2004,
Neoplasma,
K Tachi-Shinkawa, and
Y Kuroda, and
K Morimoto, and
A Koizumi
January 1988,
Radiobiologiia,
K Tachi-Shinkawa, and
Y Kuroda, and
K Morimoto, and
A Koizumi
January 1981,
Carcinogenesis,
K Tachi-Shinkawa, and
Y Kuroda, and
K Morimoto, and
A Koizumi
January 1987,
Mutation research,
K Tachi-Shinkawa, and
Y Kuroda, and
K Morimoto, and
A Koizumi
October 1985,
Carcinogenesis,
K Tachi-Shinkawa, and
Y Kuroda, and
K Morimoto, and
A Koizumi
January 1988,
Mutation research,
