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Behavioral effects of cyclo (Leu-Gly) (cLG), administered either acutely or chronically, were assessed in combination with haloperidol in the rat. cLG administered chronically, produced a significant reduction in the increase in apomorphine-induced stereotypy produced by chronic haloperidol infusion. On the other hand, the same dose of cLG which reduced this induction of dopamine receptor supersensitivity due to chronic haloperidol treatment, failed to produce a change in the potency of haloperidol in blocking conditioned avoidance responding in the rat. Furthermore, degeneration-induced supersensitivity of dopamine neurons, produced by unilateral destruction of the nigrostriatal pathway, was not reduced by acute or chronic treatment with cLG as measured by apomorphine-induced rotation. These data suggest that cLG may decrease motor system side effects thought to be caused by chronic antipsychotic administration without affecting the therapeutic efficacy of the antipsychotic agent.
A J Bean, and
R J Elgin, and
D M Cooper, and
G E Martin
January 1984,
Peptides,
A J Bean, and
R J Elgin, and
D M Cooper, and
G E Martin
May 1983,
Life sciences,
A J Bean, and
R J Elgin, and
D M Cooper, and
G E Martin
January 1986,
Peptides,
A J Bean, and
R J Elgin, and
D M Cooper, and
G E Martin
January 1984,
Life sciences,
A J Bean, and
R J Elgin, and
D M Cooper, and
G E Martin
November 1980,
Pharmacology, biochemistry, and behavior,
A J Bean, and
R J Elgin, and
D M Cooper, and
G E Martin
November 1979,
Proceedings of the National Academy of Sciences of the United States of America,
A J Bean, and
R J Elgin, and
D M Cooper, and
G E Martin
January 1980,
Pharmacology, biochemistry, and behavior,
A J Bean, and
R J Elgin, and
D M Cooper, and
G E Martin
January 1990,
Biopolymers,
A J Bean, and
R J Elgin, and
D M Cooper, and
G E Martin
April 1990,
Acta crystallographica. Section B, Structural science,
A J Bean, and
R J Elgin, and
D M Cooper, and
G E Martin
January 1984,
Psychopharmacology,
