The exact site of an interventricular septal defect (VSD) is important mainly to program surgical treatment. The present study takes into consideration the possibility of the axial angiocardiographic method to identify the site of the interventricular septal defect. With this goal 126 cases of VSD in infancy were retrospectively studied with left ventriculograms using angled "long-axial" and "four chambers" views. In 62 cases the anatomic-angiographic correlation of the VSD site was reached, and was confirmed at surgery. The most frequent localization of the VSD was perimembranous (89 cases, 70%). The rarest localizations were the sub-arterial and the multiple VSD. The personal experience agrees with the data found in literature, namely that angiocardiography performed with axial views has an elevated diagnostic reliability in the various types of VSD.