Biomaterial Database

Gill developmental program in the teleost mandibular arch. 2022

Mathi Thiruppathy, and Peter Fabian, and J Andrew Gillis, and J Gage Crump

Eli and Edythe Broad California Institute for Regenerative Medicine Center for Regenerative Medicine and Stem Cell Research, Department of Stem Cell Biology and Regenerative Medicine, University of Southern California Keck School of Medicine, Los Angeles, United States.

Whereas no known living vertebrate possesses gills derived from the jaw-forming mandibular arch, it has been proposed that the jaw arose through modifications of an ancestral mandibular gill. Here, we show that the zebrafish pseudobranch, which regulates blood pressure in the eye, develops from mandibular arch mesenchyme and first pouch epithelia and shares gene expression, enhancer utilization, and developmental gata3 dependence with the gills. Combined with work in chondrichthyans, our findings in a teleost fish point to the presence of a mandibular pseudobranch with serial homology to gills in the last common ancestor of jawed vertebrates, consistent with a gill origin of vertebrate jaws.

UI	MeSH Term	Description	Entries
D007568	Jaw	Bony structure of the mouth that holds the teeth. It consists of the MANDIBLE and the MAXILLA.	Jaws
D001934	Branchial Region	A region, of SOMITE development period, that contains a number of paired arches, each with a mesodermal core lined by ectoderm and endoderm on the two sides. In lower aquatic vertebrates, branchial arches develop into GILLS. In higher vertebrates, the arches forms outpouchings and develop into structures of the head and neck. Separating the arches are the branchial clefts or grooves.	Branchial Arches,Branchial Clefts,Pharyngeal Arches,Visceral Arches,Branchial Arch,Branchial Grooves,Pharyngeal Arch,Pharyngeal Clefts,Pharyngeal Grooves,Visceral Arch,Arch, Branchial,Arch, Pharyngeal,Arch, Visceral,Arches, Branchial,Arches, Pharyngeal,Arches, Visceral,Archs, Pharyngeal,Branchial Cleft,Branchial Groove,Branchial Regions,Cleft, Branchial,Cleft, Pharyngeal,Clefts, Branchial,Clefts, Pharyngeal,Groove, Branchial,Groove, Pharyngeal,Grooves, Branchial,Grooves, Pharyngeal,Pharyngeal Archs,Pharyngeal Cleft,Pharyngeal Groove,Region, Branchial,Regions, Branchial
D005075	Biological Evolution	The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.	Evolution, Biological
D005880	Gills	Paired respiratory organs of fishes and some amphibians that are analogous to lungs. They are richly supplied with blood vessels by which oxygen and carbon dioxide are exchanged directly with the environment.	Gill
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015027	Zebrafish	An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. Zebrafish is a model organism for drug assay and cancer research.	Brachydanio rerio,Danio rerio,B. rerio,D. rerio,Zebra Fish,Zebra Fishes,Zebra danio,Zebrafishes,D. rerios,Fishes, Zebra,Zebra danios,danio, Zebra