[General and local humoral immunity in patients with peptic ulcer]. 1987

O V Vinogradskiĭ, and Iu S Malov, and V N Kulyga, and S V Dudarenko, and M N Paskhina

Systemic and local humoral immunity and nonspecific defense factors were investigated in 88 patients with duodenal peptic ulcers and 18 patients with gastric ulcers. In acute conditions, nonspecific defence was depressed and blood IgG level was increased in peptic ulcer patients. An increase in complement titre, C3 and lysozyme, and a decrease in IgG were recorded after treatment, although normal levels were never attained. Salivary, gastric-juice and duodenal-content secretory IgA levels were characteristically increased during acute phases of peptic ulcer; salivary IgA declined after treatment. The disturbance of nonspecific defence, systemic and local humoral immunity, demonstrated in patients with peptic ulcers, may be regarded as a possible ulcerogenic mechanism.

UI MeSH Term Description Entries
D007136 Immunoglobulins Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses. Globulins, Immune,Immune Globulin,Immune Globulins,Immunoglobulin,Globulin, Immune
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009113 Muramidase A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17. Lysozyme,Leftose,N-Acetylmuramide Glycanhydrolase,Glycanhydrolase, N-Acetylmuramide,N Acetylmuramide Glycanhydrolase
D010437 Peptic Ulcer Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS). Gastroduodenal Ulcer,Marginal Ulcer,Gastroduodenal Ulcers,Marginal Ulcers,Peptic Ulcers,Ulcer, Gastroduodenal,Ulcer, Marginal,Ulcer, Peptic,Ulcers, Gastroduodenal,Ulcers, Marginal,Ulcers, Peptic
D003176 Complement C3 A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase. C3 Complement,C3 Precursor,Complement 3,Complement C3 Precursor,Complement Component 3,Precursor-Complement 3,Pro-C3,Pro-Complement 3,C3 Precursor, Complement,C3, Complement,Complement, C3,Component 3, Complement,Precursor Complement 3,Precursor, C3,Precursor, Complement C3,Pro C3,Pro Complement 3
D005260 Female Females
D005750 Gastric Juice The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651) Gastric Juices,Juice, Gastric,Juices, Gastric
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000208 Acute Disease Disease having a short and relatively severe course. Acute Diseases,Disease, Acute,Diseases, Acute

Related Publications

O V Vinogradskiĭ, and Iu S Malov, and V N Kulyga, and S V Dudarenko, and M N Paskhina
June 1990, Vrachebnoe delo,
O V Vinogradskiĭ, and Iu S Malov, and V N Kulyga, and S V Dudarenko, and M N Paskhina
May 1986, Vrachebnoe delo,
O V Vinogradskiĭ, and Iu S Malov, and V N Kulyga, and S V Dudarenko, and M N Paskhina
May 1991, Vrachebnoe delo,
O V Vinogradskiĭ, and Iu S Malov, and V N Kulyga, and S V Dudarenko, and M N Paskhina
January 1990, Klinicheskaia khirurgiia,
O V Vinogradskiĭ, and Iu S Malov, and V N Kulyga, and S V Dudarenko, and M N Paskhina
April 1986, Polski tygodnik lekarski (Warsaw, Poland : 1960),
O V Vinogradskiĭ, and Iu S Malov, and V N Kulyga, and S V Dudarenko, and M N Paskhina
January 1981, Terapevticheskii arkhiv,
O V Vinogradskiĭ, and Iu S Malov, and V N Kulyga, and S V Dudarenko, and M N Paskhina
January 1990, Vrachebnoe delo,
O V Vinogradskiĭ, and Iu S Malov, and V N Kulyga, and S V Dudarenko, and M N Paskhina
September 1980, Vrachebnoe delo,
O V Vinogradskiĭ, and Iu S Malov, and V N Kulyga, and S V Dudarenko, and M N Paskhina
January 1990, Terapevticheskii arkhiv,
O V Vinogradskiĭ, and Iu S Malov, and V N Kulyga, and S V Dudarenko, and M N Paskhina
January 1981, Vrachebnoe delo,
Copied contents to your clipboard!