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It has been recently suggested that nitrofurantoin may induce symptoms of interstitial cystitis by acting as a surface active agent that destroys glycosaminoglycan (GAG) on the bladder surface. Evidence accumulated over the past decade has demonstrated that the bladder surface GAG prevents bacterial adherence. In this experiment, exposure of the bladder lumen to nitrofurantoin at more than twice the therapeutic concentration did not destroy the bladder GAG layer (as evidenced by periodic acid-Schiff histochemistry) nor increase bacterial adherence as did a true surface active agent (Triton X-100). Acid treatment as well as all tested organic solvents except 50% dimethyl sulfoxide (DMSO) also removed the bladder GAG layer and increased bacterial adherence. These results indicate that neither nitrofurantoin nor 50% DMSO has adverse effects on the bladder surface and thus is unlikely to initiate the interstitial cystitis symptom complex by means of surfactant activity.
M R Ruggieri, and
P M Hanno, and
R M Levin
July 1965,
Investigative urology,
M R Ruggieri, and
P M Hanno, and
R M Levin
March 1969,
Investigative urology,
M R Ruggieri, and
P M Hanno, and
R M Levin
October 1978,
Urology,
M R Ruggieri, and
P M Hanno, and
R M Levin
April 1972,
Delaware medical journal,
M R Ruggieri, and
P M Hanno, and
R M Levin
January 1982,
The Journal of membrane biology,
M R Ruggieri, and
P M Hanno, and
R M Levin
November 1967,
Investigative urology,
M R Ruggieri, and
P M Hanno, and
R M Levin
January 1977,
Die Naturwissenschaften,
M R Ruggieri, and
P M Hanno, and
R M Levin
June 1988,
Pflugers Archiv : European journal of physiology,
M R Ruggieri, and
P M Hanno, and
R M Levin
December 1995,
The Anatomical record,
M R Ruggieri, and
P M Hanno, and
R M Levin
July 2002,
European journal of pharmacology,
