-transparent.png){kind=logo}
Besides other mediators like prostaglandins, kinins and histamine, oxygen radicals potentiate inflammations. Vitamin E as natural antioxidant could scavenge radicals produced during an inflammation and therefore reduce the inflammatory response. In experiments with male Wistar rats maintained on a diet deficient in or supplemented with vitamin E for 6 weeks the influence of the administration of DL-alpha-tocopherol on the inflammation of the right hind paw was tested. The irritation produced by injection of Freund's complete adjuvants was observed for 21 days. Measuring the thickness of the paw and the activity of acid phosphatase in the paw tissue there was no difference in the intensity of inflammation among the control and the vitamin-E-deficient diet groups. The supplementation with a pharmacological dose of tocopherol (324 mg DL-alpha-tocopherol/100 g food) had no effect on the inflammation of animals with different vitamin E supplements. Differences in the antioxidant status (contents of tocopherol and malondialdehyde in several organs, activity of creatine kinase in plasma) among the groups were mainly linked to the various tocopherol supplies. The irritation increased the lipid peroxidation in liver mitochondria and the activity of creatine kinase in the plasma. The data show no influence of vitamin E on this kind of inflammation.
M Sobirey, and
E Schlotzer, and
K Manns, and
I Elmadfa
October 1979,
Agents and actions,
M Sobirey, and
E Schlotzer, and
K Manns, and
I Elmadfa
November 1963,
Ceskoslovenska fysiologie,
M Sobirey, and
E Schlotzer, and
K Manns, and
I Elmadfa
February 2005,
Indian journal of experimental biology,
M Sobirey, and
E Schlotzer, and
K Manns, and
I Elmadfa
January 1954,
Rendiconti - Istituto superiore di sanita,
M Sobirey, and
E Schlotzer, and
K Manns, and
I Elmadfa
April 1983,
Biochemical medicine,
M Sobirey, and
E Schlotzer, and
K Manns, and
I Elmadfa
March 1973,
Bollettino della Societa italiana di biologia sperimentale,
M Sobirey, and
E Schlotzer, and
K Manns, and
I Elmadfa
October 1984,
Toxicology letters,
M Sobirey, and
E Schlotzer, and
K Manns, and
I Elmadfa
January 2006,
Journal of medicinal food,
M Sobirey, and
E Schlotzer, and
K Manns, and
I Elmadfa
July 1999,
Kidney international. Supplement,
M Sobirey, and
E Schlotzer, and
K Manns, and
I Elmadfa
November 1997,
Anesthesia and analgesia,
