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The concentration and distribution of pancreatic polypeptide (PP) was studied in hyperglycemic obese (ob/ob) mice and homozygous (+/+) controls. By radioimmunoassay, the concentration of PP in the pancreas of ob/ob mice was greater both in the duodenal lobe (70.7%) and in the body and tail (66.3%) when compared to identical areas of control pancreases. Analysis of immunostained pancreatic tissue indicated that the number of PP cells per islet cross-section was significantly increased (58%) in the ob/ob tissue. The calculated total number of PP cells per average islet was elevated three times in the ob/ob islet. However, the proportion PP cell volume relative to the islet volume in ob/ob was one-half that of control islets. These results clearly demonstrate an elevation in both the number of PP cells per islet and the concentration of PP in the diabetic ob/ob murine pancreas.
R L Gingerich, and
D J Gersell, and
M H Greider, and
E H Finke, and
P E Lacy
January 1992,
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R L Gingerich, and
D J Gersell, and
M H Greider, and
E H Finke, and
P E Lacy
December 1968,
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R L Gingerich, and
D J Gersell, and
M H Greider, and
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P E Lacy
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R L Gingerich, and
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September 1977,
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R L Gingerich, and
D J Gersell, and
M H Greider, and
E H Finke, and
P E Lacy
August 1984,
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R L Gingerich, and
D J Gersell, and
M H Greider, and
E H Finke, and
P E Lacy
September 1967,
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R L Gingerich, and
D J Gersell, and
M H Greider, and
E H Finke, and
P E Lacy
January 1979,
Hormone research,
R L Gingerich, and
D J Gersell, and
M H Greider, and
E H Finke, and
P E Lacy
October 1965,
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R L Gingerich, and
D J Gersell, and
M H Greider, and
E H Finke, and
P E Lacy
May 1990,
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R L Gingerich, and
D J Gersell, and
M H Greider, and
E H Finke, and
P E Lacy
January 1962,
Zeitschrift fur Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948),
