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A type of mastopathy is unique to insulin-dependent diabetic patients. The characteristic change is a connective tissue overgrowth with vasculitis and some proliferation of duct epithelium. It is not the type of change typically associated with an increased risk of breast cancer. Clinically this change is indistinguishable by physical or radiographic findings from breast malignancy. Eleven biopsies showing these characteristics were performed on insulin-dependent patients who had diabetes mellitus from childhood. Every patient had some major complication of diabetes mellitus, usually diabetic retinopathy. In every instance the mastopathy continued to manifest itself as a part of the healing process. The probability is that this is an evidence in the breast of collagen cross-linking changes seen in patients with diabetes mellitus. This observation should help in the supervision of patients with a clinical background compatible with this study.
B F Byrd, and
W H Hartmann, and
L S Graham, and
H H Hogle
August 1991,
Clinical radiology,
B F Byrd, and
W H Hartmann, and
L S Graham, and
H H Hogle
October 1997,
Breast cancer (Tokyo, Japan),
B F Byrd, and
W H Hartmann, and
L S Graham, and
H H Hogle
March 1970,
British medical journal,
B F Byrd, and
W H Hartmann, and
L S Graham, and
H H Hogle
January 1986,
Diabetes research and clinical practice,
B F Byrd, and
W H Hartmann, and
L S Graham, and
H H Hogle
January 1983,
L'Annee therapeutique et clinique en ophtalmologie,
B F Byrd, and
W H Hartmann, and
L S Graham, and
H H Hogle
January 2002,
Rays,
B F Byrd, and
W H Hartmann, and
L S Graham, and
H H Hogle
December 1983,
Science (New York, N.Y.),
B F Byrd, and
W H Hartmann, and
L S Graham, and
H H Hogle
November 1983,
British medical journal (Clinical research ed.),
B F Byrd, and
W H Hartmann, and
L S Graham, and
H H Hogle
December 1983,
Diabete & metabolisme,
B F Byrd, and
W H Hartmann, and
L S Graham, and
H H Hogle
January 1989,
Diabete & metabolisme,
