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Experiments were performed in order to determine whether exogenous cytidine (5') diphosphocholine (CDP-choline) opposes the effects of an acute hypobaric hypoxia on the metabolism of catecholamines in rat striatum and hypothalamus. Hypoxia decreased striatal HVA, DOPAC, 3 MT, hypothalamic norepinephrine (NE), and increased both striatal and hypothalamic dopamine (DA). CDP-choline (1000 mg X kg-1 p.o.; 1 or 3 days) was devoid of effects in normoxia, but partially reversed 3 MT, NE and DA changes, potentiated the HVA and DOPAC decrease in hypoxic rats. Our results suggest that hypoxia could impair neurotransmitter release and that treatment with CDP-choline (acute, and especially subacute administration) opposes this impairment.
C Saligaut, and
M Daoust, and
N Moore, and
F Boismare
May 1979,
Archives internationales de pharmacodynamie et de therapie,
C Saligaut, and
M Daoust, and
N Moore, and
F Boismare
January 2000,
Annals of the New York Academy of Sciences,
C Saligaut, and
M Daoust, and
N Moore, and
F Boismare
February 2003,
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology,
C Saligaut, and
M Daoust, and
N Moore, and
F Boismare
December 1984,
Neuropharmacology,
C Saligaut, and
M Daoust, and
N Moore, and
F Boismare
January 1993,
Brain research bulletin,
C Saligaut, and
M Daoust, and
N Moore, and
F Boismare
January 1992,
Journal of neural transmission. Parkinson's disease and dementia section,
C Saligaut, and
M Daoust, and
N Moore, and
F Boismare
November 1974,
Neuropharmacology,
C Saligaut, and
M Daoust, and
N Moore, and
F Boismare
January 1978,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
C Saligaut, and
M Daoust, and
N Moore, and
F Boismare
July 2013,
Pediatric research,
C Saligaut, and
M Daoust, and
N Moore, and
F Boismare
August 1972,
Biochemical pharmacology,
