Egyptian Mediterranean coast receives significant amounts of polycyclic aromatic hydrocarbons (PAHs) from industrial exhausts, riverine inputs, maritime shipping and fishers, and oil and natural gas production and exploration. The present study considers the first exhaustive assessment for the dissolved PAHs along the Egyptian Mediterranean coast (Alexandria to Manzallah) to monitor their spatial distribution and investigate the effect of the marine currents and the role of microorganisms in their distribution. Surface water levels ranged between 124.97 and 301.02 ng L-1 with an average 223.68 ± 41.11 ng L-1. The distribution increases from west to east based on the water circulation in the Mediterranean Sea. The levels in near shore stations were lower than those of middle and onshore stations. The intensive existence of micro-organisms near shore stations consumes great part of PAHs, while this bio-remediation process decreases gradually away from the shoreline leaving relative high concentrations of dissolved PAHs in the middle and onshore stations. Middle and deep-water levels ranged between 312.75 and 1042.95 ng L-1 with an average 633.47 ± 225.53 ng L-1. Deeper waters showed higher PAHs concentrations where the average concentrations of 50 m stations (868.12 ± 138.35 ng L-1) ˃ 30 m stations (629.49 ± 143.85 ng L-1) ˃ 10 m stations (402.79 ± 59.46 ng L-1). The wind-induced waves re-suspend rich PAHs sediment particles to increase its concentration in the water column. Carcinogenic toxic equivalent quotient (TEQ) for total detected PAHs in the middle and deep water represented more than double (75.46 ng TEQ L-1) the value in the surface water (34.76 ng TEQ L-1). The diagnostic ratios and principal component analysis indicated mainly pyrogenic origin in surface, middle, and deep waters.