BIOMAT Database Logo BIOMAT Database Logo

Sequence homology in the metalloproteins; purple acid phosphatase from beef spleen and uteroferrin from porcine uterus. 1987

D F Hunt, and J R Yates, and J Shabanowitz, and N Z Zhu, and T Zirino, and B A Averill, and S T Daurat-Larroque, and J G Shewale, and R M Roberts, and K Brew

The primary structures of purple acid phosphatase and uteroferrin, two iron-binding glycoproteins isolated from beef spleen and porcine uterine fluids, respectively, have been examined by a combination of tandem mass spectrometry and classical Edman sequencing methods. Reported here are amino acid sequence data covering more than 90% of the primary structures for these two proteins. The sequence data reveal an unexpectedly high degree of homology, greater than 90%, for these two proteins.

UI MeSH Term Description Entries
D007527 Isoenzymes Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics. Alloenzyme,Allozyme,Isoenzyme,Isozyme,Isozymes,Alloenzymes,Allozymes
D008667 Metalloproteins Proteins that have one or more tightly bound metal ions forming part of their structure. (Dorland, 28th ed) Metalloprotein
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D005260 Female Females
D000071681 Tartrate-Resistant Acid Phosphatase One of several acid phosphatases in humans, other mammals, plants, and a few prokaryotes. The protein fold of tartrate-resistant acid phosphatase (TRAP) resembles that of the catalytic domain of plant purple acid phosphatase and other serine/threonine-protein phosphatases that also contain a metallophosphoesterase domain. One gene produces the various forms which include purple acid phosphatases from spleen and other tissues. Tartrate-resistant acid phosphatase is a biomarker for pathological states in which it is over-expressed. Such conditions include GAUCHER DISEASE; HODGKIN DISEASE; BONE RESORPTION; and NEOPLASM METASTASIS. AcPase V,Acid Phosphatase V,TRAP Type 5 AcPase,TRAcP,Tartrate-Resistant Acid Phosphatase Type 5,Type 5 Acid Phosphatase,Uteroferrin,Acid Phosphatase, Tartrate-Resistant,Phosphatase V, Acid,Phosphatase, Tartrate-Resistant Acid,Tartrate Resistant Acid Phosphatase,Tartrate Resistant Acid Phosphatase Type 5,V, AcPase,V, Acid Phosphatase
D000135 Acid Phosphatase An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2. Acid beta-Glycerophosphatase,Acid beta Glycerophosphatase
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012689 Sequence Homology, Nucleic Acid The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function. Base Sequence Homology,Homologous Sequences, Nucleic Acid,Homologs, Nucleic Acid Sequence,Homology, Base Sequence,Homology, Nucleic Acid Sequence,Nucleic Acid Sequence Homologs,Nucleic Acid Sequence Homology,Sequence Homology, Base,Base Sequence Homologies,Homologies, Base Sequence,Sequence Homologies, Base
D013058 Mass Spectrometry An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers. Mass Spectroscopy,Spectrometry, Mass,Spectroscopy, Mass,Spectrum Analysis, Mass,Analysis, Mass Spectrum,Mass Spectrum Analysis,Analyses, Mass Spectrum,Mass Spectrum Analyses,Spectrum Analyses, Mass

Related Publications

D F Hunt, and J R Yates, and J Shabanowitz, and N Z Zhu, and T Zirino, and B A Averill, and S T Daurat-Larroque, and J G Shewale, and R M Roberts, and K Brew
Direct electrochemistry of porcine purple acid phosphatase (uteroferrin).
August 2004, Biochemistry,
D F Hunt, and J R Yates, and J Shabanowitz, and N Z Zhu, and T Zirino, and B A Averill, and S T Daurat-Larroque, and J G Shewale, and R M Roberts, and K Brew
Resonance Raman scattering from uteroferrin, the purple glycoprotein of the porcine uterus.
September 1979, The Journal of biological chemistry,
D F Hunt, and J R Yates, and J Shabanowitz, and N Z Zhu, and T Zirino, and B A Averill, and S T Daurat-Larroque, and J G Shewale, and R M Roberts, and K Brew
Kinetics and optical spectroscopic studies on the purple acid phosphatase from beef spleen.
July 1981, Biochemistry,
D F Hunt, and J R Yates, and J Shabanowitz, and N Z Zhu, and T Zirino, and B A Averill, and S T Daurat-Larroque, and J G Shewale, and R M Roberts, and K Brew
Transfer of iron from uteroferrin (purple acid phosphatase) to transferrin related to acid phosphatase activity.
July 1990, The Journal of biological chemistry,
D F Hunt, and J R Yates, and J Shabanowitz, and N Z Zhu, and T Zirino, and B A Averill, and S T Daurat-Larroque, and J G Shewale, and R M Roberts, and K Brew
1H NMR and NOE studies of the purple acid phosphatases from porcine uterus and bovine spleen.
June 1992, Biochemistry,
D F Hunt, and J R Yates, and J Shabanowitz, and N Z Zhu, and T Zirino, and B A Averill, and S T Daurat-Larroque, and J G Shewale, and R M Roberts, and K Brew
Uteroferrin and the purple acid phosphatases.
January 1983, Advances in inorganic biochemistry,
D F Hunt, and J R Yates, and J Shabanowitz, and N Z Zhu, and T Zirino, and B A Averill, and S T Daurat-Larroque, and J G Shewale, and R M Roberts, and K Brew
EPR signal, purple color, and iron binding in porcine uteroferrin.
February 1982, The Journal of biological chemistry,
D F Hunt, and J R Yates, and J Shabanowitz, and N Z Zhu, and T Zirino, and B A Averill, and S T Daurat-Larroque, and J G Shewale, and R M Roberts, and K Brew
The type 5, acid phosphatase from spleen of humans with hairy cell leukemia. Purification, properties, immunological characterization, and comparison with porcine uteroferrin.
May 1985, The Journal of biological chemistry,
D F Hunt, and J R Yates, and J Shabanowitz, and N Z Zhu, and T Zirino, and B A Averill, and S T Daurat-Larroque, and J G Shewale, and R M Roberts, and K Brew
Purification and characterization of a purple acid phosphatase from rat spleen.
January 1984, Journal of biochemistry,
D F Hunt, and J R Yates, and J Shabanowitz, and N Z Zhu, and T Zirino, and B A Averill, and S T Daurat-Larroque, and J G Shewale, and R M Roberts, and K Brew
Sequence homology between purple acid phosphatases and phosphoprotein phosphatases. Are phosphoprotein phosphatases metalloproteins containing oxide-bridged dinuclear metal centers?
April 1990, FEBS letters,
Copied contents to your clipboard!