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Hydrogen sulfide (H2S) induces acute and lethal toxicity at high concentrations. However, no specific antidotes for H2S poisoning have been approved. Liposomal methemoglobin (metHb@Lipo) was developed as an antidote for cyanide poisoning. As the toxic mechanism of H2S poisoning is the same as that of cyanide poisoning, metHb@Lipo could potentially be used as an antidote for H2S poisoning. In this study, we evaluated the antidotal efficacy of metHb@Lipo against H2S poisoning. Stopped-flow rapid-scan spectrophotometry clearly showed that metHb@Lipo scavenged H2S rapidly. Additionally, metHb@Lipo showed cytoprotective effects against H2S exposure in H9c2 cells by maintaining mitochondrial function. MetHb@Lipo treatment also improved the survival rate after H2S exposure in vivo, with the maintenance of cytochrome c oxidase activity and suppression of metabolic acidosis. Moreover, metHb@Lipo therapy maintained significant antidotal efficacy even after 1-year-storage at 4-37 °C. In conclusion, metHb@Lipo is a candidate antidote for H2S poisoning.
Yuto Suzuki, and
Kazuaki Taguchi, and
Tomoko Kure, and
Yuki Enoki, and
Masaki Otagiri, and
Hiromi Sakai, and
Kazuaki Matsumoto
November 1981,
American Industrial Hygiene Association journal,
Yuto Suzuki, and
Kazuaki Taguchi, and
Tomoko Kure, and
Yuki Enoki, and
Masaki Otagiri, and
Hiromi Sakai, and
Kazuaki Matsumoto
January 1983,
Journal of toxicology. Clinical toxicology,
Yuto Suzuki, and
Kazuaki Taguchi, and
Tomoko Kure, and
Yuki Enoki, and
Masaki Otagiri, and
Hiromi Sakai, and
Kazuaki Matsumoto
February 2015,
Clinical toxicology (Philadelphia, Pa.),
Yuto Suzuki, and
Kazuaki Taguchi, and
Tomoko Kure, and
Yuki Enoki, and
Masaki Otagiri, and
Hiromi Sakai, and
Kazuaki Matsumoto
March 2011,
Journal of analytical toxicology,
Yuto Suzuki, and
Kazuaki Taguchi, and
Tomoko Kure, and
Yuki Enoki, and
Masaki Otagiri, and
Hiromi Sakai, and
Kazuaki Matsumoto
November 1985,
The American journal of emergency medicine,
Yuto Suzuki, and
Kazuaki Taguchi, and
Tomoko Kure, and
Yuki Enoki, and
Masaki Otagiri, and
Hiromi Sakai, and
Kazuaki Matsumoto
November 2014,
Clinica chimica acta; international journal of clinical chemistry,
Yuto Suzuki, and
Kazuaki Taguchi, and
Tomoko Kure, and
Yuki Enoki, and
Masaki Otagiri, and
Hiromi Sakai, and
Kazuaki Matsumoto
April 1978,
Canadian Medical Association journal,
Yuto Suzuki, and
Kazuaki Taguchi, and
Tomoko Kure, and
Yuki Enoki, and
Masaki Otagiri, and
Hiromi Sakai, and
Kazuaki Matsumoto
May 1950,
Imprensa medica,
Yuto Suzuki, and
Kazuaki Taguchi, and
Tomoko Kure, and
Yuki Enoki, and
Masaki Otagiri, and
Hiromi Sakai, and
Kazuaki Matsumoto
April 1987,
North Carolina medical journal,
Yuto Suzuki, and
Kazuaki Taguchi, and
Tomoko Kure, and
Yuki Enoki, and
Masaki Otagiri, and
Hiromi Sakai, and
Kazuaki Matsumoto
February 1979,
Journal of occupational medicine. : official publication of the Industrial Medical Association,
