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The effects of beclomethasone, dipropionate aerosol (DBA) (400 microgram/day) on clinical course, pulmonary function, and pituitary-adrenal function was studied in 34 steroid-dependent asthmatic children. Asthma severity was assessed by daily symptom and medication scores, peak flow measured three times a day, and weekly spirometry. Pituitary-adrenal function was evaluated by diurnal cortisol levels, cortisol responses to intravenous (IV) corticotropin (ACTH), and steroid responses to IV metyrapone. After 12 weeks of BDA therapy, 30 of 34 patients no longer required prednisone. Mean weekly symptom and medication scores and the number of attacks decreased significantly (P less than .01)). A significant improvement was demonstrated in the patients' peak flow (P less than .01), forced expiratory volume in one second, and maximum midexpiratory flow rates (P less than .01). Thirty of the 34 patients initially had abnormal metyrapone responses, 28 had abnormal diurnal cortisol levels, whereas only 14 had abnormal IV ACTH response tests. Although significant improvement was noted in the mean metyrapone and diurnal cortisol tests, only partial recovery of pituitary-adrenal function was observed in 20 patients, complete recovery in 5, and no change in 9. BDA was found to be therapeutically superior to oral steroids in the group of steroid-dependent asthmatic children and produced no serious adverse effects.
H Kershnar, and
R Klein, and
D Waldman, and
W Berger, and
G Rachelefsky, and
R Katz, and
S Siegel
March 1973,
British medical journal,
H Kershnar, and
R Klein, and
D Waldman, and
W Berger, and
G Rachelefsky, and
R Katz, and
S Siegel
July 1976,
Chest,
H Kershnar, and
R Klein, and
D Waldman, and
W Berger, and
G Rachelefsky, and
R Katz, and
S Siegel
October 1976,
JAMA,
H Kershnar, and
R Klein, and
D Waldman, and
W Berger, and
G Rachelefsky, and
R Katz, and
S Siegel
December 1975,
Revue medicale de Liege,
H Kershnar, and
R Klein, and
D Waldman, and
W Berger, and
G Rachelefsky, and
R Katz, and
S Siegel
February 1978,
Monatsschrift fur Kinderheilkunde,
H Kershnar, and
R Klein, and
D Waldman, and
W Berger, and
G Rachelefsky, and
R Katz, and
S Siegel
August 1980,
The Practitioner,
H Kershnar, and
R Klein, and
D Waldman, and
W Berger, and
G Rachelefsky, and
R Katz, and
S Siegel
July 1983,
Pediatrics,
H Kershnar, and
R Klein, and
D Waldman, and
W Berger, and
G Rachelefsky, and
R Katz, and
S Siegel
July 1975,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
H Kershnar, and
R Klein, and
D Waldman, and
W Berger, and
G Rachelefsky, and
R Katz, and
S Siegel
September 1973,
Clinical allergy,
H Kershnar, and
R Klein, and
D Waldman, and
W Berger, and
G Rachelefsky, and
R Katz, and
S Siegel
December 1978,
The New England journal of medicine,
