Biomaterial Database

Effects of intrapleural pressure on phrenic nerve activity. 1986

B P Lee, and S T Chiang, and J C Hwang

In order to evaluate the effect of changing respiratory mechanics on the relation between respiratory mechanical output and phrenic activity, we simultaneously measured ventilatory output from the trace of pneumotachograph and changes in phrenic nerve activity before and after pneumothorax in alpha-chloralose anesthetized dogs. After pneumothorax, the dynamic lung compliance, inspiratory duration and tidal volume were decreased significantly, whereas the integrated peak amplitude and the rate of rise of phrenic neural output were increased substantially. The difference between respiratory mechanical output and phrenic activity was also significant (p less than 0.05). As shown from the results, the increase of phrenic response to pneumothorax may be mediated through intrapulmonary receptors along the vagal afferent rather than through the changes in chemical drive.

UI	MeSH Term	Description	Entries
D008170	Lung Compliance	The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)	Compliance, Lung,Compliances, Lung,Lung Compliances
D008297	Male		Males
D010791	Phrenic Nerve	The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.	Nerve, Phrenic,Nerves, Phrenic,Phrenic Nerves
D011031	Pneumothorax, Artificial	Injection of air or a more slowly absorbed gas such as nitrogen, into the PLEURAL CAVITY to collapse the lung.	Artificial Pneumothorax,Artificial Pneumothoraxs,Pneumothoraxs, Artificial
D011312	Pressure	A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Pressures
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001696	Biomechanical Phenomena	The properties, processes, and behavior of biological systems under the action of mechanical forces.	Biomechanics,Kinematics,Biomechanic Phenomena,Mechanobiological Phenomena,Biomechanic,Biomechanic Phenomenas,Phenomena, Biomechanic,Phenomena, Biomechanical,Phenomena, Mechanobiological,Phenomenas, Biomechanic