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Intravenous administration of high-dose pentobarbital has been proposed as a treatment for elevated intracranial pressure refractory to other measures in brain-injured patients. The purpose of this clinical study was to examine the pharmacokinetics of high-dose continuous intravenous infusion of pentobarbital in this critical care setting. Six patients received a 25-34 mg/kg intravenous loading dose followed by a 1-3 mg/kg/h continuous infusion for 61-190 hours. Dosing rates were adjusted based on the patient's clinical status. The mean clearance was 0.72 ml/min/kg, with a volume of distribution (Vd) of 1.03 L/kg and a terminal half-life of 19.1 h. Considerable variation in individual patient parameters was observed. In addition, a change in clearance was suggested in patients requiring a longer infusion duration.
D P Wermeling, and
R A Blouin, and
W H Porter, and
R P Rapp, and
P A Tibbs
October 1985,
Clinical pharmacology and therapeutics,
D P Wermeling, and
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W H Porter, and
R P Rapp, and
P A Tibbs
July 1987,
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D P Wermeling, and
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January 1979,
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D P Wermeling, and
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D P Wermeling, and
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May 1975,
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D P Wermeling, and
R A Blouin, and
W H Porter, and
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P A Tibbs
December 1987,
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D P Wermeling, and
R A Blouin, and
W H Porter, and
R P Rapp, and
P A Tibbs
January 1980,
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D P Wermeling, and
R A Blouin, and
W H Porter, and
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P A Tibbs
February 1973,
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D P Wermeling, and
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P A Tibbs
November 1988,
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D P Wermeling, and
R A Blouin, and
W H Porter, and
R P Rapp, and
P A Tibbs
December 2000,
The Journal of trauma,
