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Anti-inflammatory flavonoid derivatives from the heartwood of Dalbergia odorifera T. Chen. 2023
Ni-Li Zan, and
Zi-Han Lu, and
Xin-Yu Wang, and
Rong-Ye Wang, and
Nai-Yun Liang, and
Hui-Xia Huo, and
Yun-Fang Zhao, and
Yue-Lin Song, and
Peng-Fei Tu, and
Jiao Zheng, and
Jun Li
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Two pairs of flavonoid enantiomers (1a/1b and 2a/2b) together with three known analogues (3-5) were isolated from the heartwood of Dalbergia odorifera T. Chen. Their structures were elucidated by extensive spectroscopic analysis (1 D and 2 D NMR, UV, IR, and HRMS) and experimental and calculated ECD data. Compound 2 features an unusual 2-methyl-3(2H)-furanone moiety forming the C-ring of flavonoid, and its putative biosynthetic pathway is also proposed. Compounds 3‒5 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC50 values of 14.7 ± 0.3 μM, 40.2 ± 1.1 μM, and 3.2 ± 0.1 μM, respectively.
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