-transparent.png){kind=logo}
Acrylamide (AA), known to induce dominant lethals in male rodents, was studied in the mouse heritable translocation test by using intraperitoneal injections on 5 consecutive days. Matings on days 7-10 following the last injection yielded a high frequency of translocation carriers in the F1 male population, which demonstrated that acrylamide is an effective inducer of translocations in postmeiotic germ cells. As an inducer of both dominant lethals and heritable translocations in late spermatids and early spermatozoa, AA is similar to alkylating agents such as ethylmethanesulfonate and ethylene oxide. However, AA's chemical structure, the nature of adducts formed with DNA, and it lack of mutagenicity in bacteria suggest a different mechanism as the basis for AA's germ cell mutagenicity.
M D Shelby, and
K T Cain, and
C V Cornett, and
W M Generoso
January 1985,
Mutation research,
M D Shelby, and
K T Cain, and
C V Cornett, and
W M Generoso
January 2004,
Cytogenetic and genome research,
M D Shelby, and
K T Cain, and
C V Cornett, and
W M Generoso
September 1980,
Mutation research,
M D Shelby, and
K T Cain, and
C V Cornett, and
W M Generoso
November 1980,
Mutation research,
M D Shelby, and
K T Cain, and
C V Cornett, and
W M Generoso
October 2016,
Biology of reproduction,
M D Shelby, and
K T Cain, and
C V Cornett, and
W M Generoso
October 1990,
Mutation research,
M D Shelby, and
K T Cain, and
C V Cornett, and
W M Generoso
October 1985,
Mutation research,
M D Shelby, and
K T Cain, and
C V Cornett, and
W M Generoso
September 1994,
Mutation research,
M D Shelby, and
K T Cain, and
C V Cornett, and
W M Generoso
December 1984,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
M D Shelby, and
K T Cain, and
C V Cornett, and
W M Generoso
April 1982,
Mutation research,
