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Polymorphonuclear leukocytes (PMNs) represent an important defensive mechanism against infectious agents. Some of their functions are impaired in old people, with a decreased effectiveness of nonspecific immunity. In vitro PMN phagocytic activity was studied with different techniques on 74 healthy subjects (20-82.5 years; 40 males, 34 females). Serum-mediated ingestion resulted to be impaired with age with a lower ratio of active PMNs and a lower activity of phagocytosing cells. The behavior of these parameters was age-related, without significant difference between males and females; the decline was found to be a continuous phenomenon with no threshold age. Serum-independent ingestion had very low values and was not impaired with aging. The present data can represent a further explanation for the finding of a higher incidence and mortality of bacterial diseases in elderly population.
G Emanuelli, and
M Lanzio, and
T Anfossi, and
S Romano, and
G Anfossi, and
G Calcamuggi
February 2003,
Yonsei medical journal,
G Emanuelli, and
M Lanzio, and
T Anfossi, and
S Romano, and
G Anfossi, and
G Calcamuggi
January 1980,
Archivos de investigacion medica,
G Emanuelli, and
M Lanzio, and
T Anfossi, and
S Romano, and
G Anfossi, and
G Calcamuggi
June 1982,
Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology,
G Emanuelli, and
M Lanzio, and
T Anfossi, and
S Romano, and
G Anfossi, and
G Calcamuggi
May 1990,
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
G Emanuelli, and
M Lanzio, and
T Anfossi, and
S Romano, and
G Anfossi, and
G Calcamuggi
February 2001,
Biology of the neonate,
G Emanuelli, and
M Lanzio, and
T Anfossi, and
S Romano, and
G Anfossi, and
G Calcamuggi
January 1989,
General pharmacology,
G Emanuelli, and
M Lanzio, and
T Anfossi, and
S Romano, and
G Anfossi, and
G Calcamuggi
January 1999,
Revista latinoamericana de microbiologia,
G Emanuelli, and
M Lanzio, and
T Anfossi, and
S Romano, and
G Anfossi, and
G Calcamuggi
October 1994,
European journal of obstetrics, gynecology, and reproductive biology,
G Emanuelli, and
M Lanzio, and
T Anfossi, and
S Romano, and
G Anfossi, and
G Calcamuggi
June 1983,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
G Emanuelli, and
M Lanzio, and
T Anfossi, and
S Romano, and
G Anfossi, and
G Calcamuggi
January 1968,
Annales medicinae experimentalis et biologiae Fenniae,
