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Nine patients with duodenal ulcer were studied before and 2--3 months after proximal gastric vagotomy (PGV). Infustion or cimetidine, 1.2 mg.kg-1h-1, reduced mean gastric acid output, in response to infusion of 1.5 microgram.kg-1h-1 of pentagastrin, by, on an average, 79.4% before and 79.1% after vagotomy. The corresponding values for pepsin output were 66.5% before and 77.0% after the operation. The values were not statistically different. Thus, in terms of per cent inhibition, cimetidine was similarly effective before and after PGV. No correlation was found between per cent reduction of acic output by vagotomy and by cimetidine. The effect of the drug was added to that of the vagotomy. Patients with relapse ulcer after vagotomy are therefore interesting candidates for cimetidine treatment.
E Aadland, and
A Berstad, and
L S Semb, and
K Bjerke
January 1975,
Scandinavian journal of gastroenterology,
E Aadland, and
A Berstad, and
L S Semb, and
K Bjerke
October 1987,
Scandinavian journal of gastroenterology,
E Aadland, and
A Berstad, and
L S Semb, and
K Bjerke
September 1968,
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E Aadland, and
A Berstad, and
L S Semb, and
K Bjerke
December 1980,
Gut,
E Aadland, and
A Berstad, and
L S Semb, and
K Bjerke
January 1974,
Scandinavian journal of gastroenterology,
E Aadland, and
A Berstad, and
L S Semb, and
K Bjerke
July 1984,
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E Aadland, and
A Berstad, and
L S Semb, and
K Bjerke
August 1984,
Lancet (London, England),
E Aadland, and
A Berstad, and
L S Semb, and
K Bjerke
March 1973,
Vestnik khirurgii imeni I. I. Grekova,
E Aadland, and
A Berstad, and
L S Semb, and
K Bjerke
January 1989,
International surgery,
E Aadland, and
A Berstad, and
L S Semb, and
K Bjerke
May 1976,
The Indian journal of medical research,
