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Humoral hypercalcemia of malignancy is a common paraneoplastic syndrome which is characterized by hypercalcemia resulting from secretion by tumors of a circulating bone-resorbing factor. Evidence suggests that in many instances this factor is an adenylate cyclase-stimulating protein which shares features with, but is distinct from, parathyroid hormone (PTH). The current report describes the purification to homogeneity from a humoral hypercalcemia of malignancy-associated tumor of a novel, basic, highly potent PTH-like adenylate cyclase-stimulating protein. This factor differs from previously described PTH-like factors with respect to size, amino acid composition, and specific activity.
W J Burtis, and
T Wu, and
C Bunch, and
J J Wysolmerski, and
K L Insogna, and
E C Weir, and
A E Broadus, and
A F Stewart
January 1988,
Proceedings of the National Academy of Sciences of the United States of America,
W J Burtis, and
T Wu, and
C Bunch, and
J J Wysolmerski, and
K L Insogna, and
E C Weir, and
A E Broadus, and
A F Stewart
December 1988,
Endocrinology,
W J Burtis, and
T Wu, and
C Bunch, and
J J Wysolmerski, and
K L Insogna, and
E C Weir, and
A E Broadus, and
A F Stewart
January 1990,
Journal of the National Cancer Institute,
W J Burtis, and
T Wu, and
C Bunch, and
J J Wysolmerski, and
K L Insogna, and
E C Weir, and
A E Broadus, and
A F Stewart
September 1988,
The New England journal of medicine,
W J Burtis, and
T Wu, and
C Bunch, and
J J Wysolmerski, and
K L Insogna, and
E C Weir, and
A E Broadus, and
A F Stewart
January 1990,
Advances in clinical chemistry,
W J Burtis, and
T Wu, and
C Bunch, and
J J Wysolmerski, and
K L Insogna, and
E C Weir, and
A E Broadus, and
A F Stewart
January 1986,
Recent progress in hormone research,
W J Burtis, and
T Wu, and
C Bunch, and
J J Wysolmerski, and
K L Insogna, and
E C Weir, and
A E Broadus, and
A F Stewart
April 1989,
The Journal of biological chemistry,
W J Burtis, and
T Wu, and
C Bunch, and
J J Wysolmerski, and
K L Insogna, and
E C Weir, and
A E Broadus, and
A F Stewart
October 1983,
The Journal of clinical investigation,
W J Burtis, and
T Wu, and
C Bunch, and
J J Wysolmerski, and
K L Insogna, and
E C Weir, and
A E Broadus, and
A F Stewart
January 1994,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
W J Burtis, and
T Wu, and
C Bunch, and
J J Wysolmerski, and
K L Insogna, and
E C Weir, and
A E Broadus, and
A F Stewart
February 1987,
Endocrinology,
