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Bile flow was re-established in rats whose bile ducts had been obstructed for 5, 10, 15 and 28 days (Groups I, II, III and IV, n = 5). The effect of i.v. secretin on bile flow in control rats, whose bile ducts had been cannulated, was minimal, but in cholestatic rats there was an immediate response which was related to the duration of the obstruction and the degree of bile duct proliferation. In 40 min the mean excess bile flow production amounted to 76, 258, 320 and 432 microliters/100 g body wt. in Groups I, II, III and IV, respectively. Choleresis was prolonged in the Group IV rats that had developed cirrhosis. Synthetic secretin had a minimal effect on bile acid and bilirubin excretion. It is postulated that the proliferating bile ductules are the site of secretin choleresis, although the possibility that reduced inactivation of the hormone plays a role cannot be excluded.
J Kountouras, and
S McKavanagh, and
M Burmicky, and
B H Billing
March 1985,
Clinical science (London, England : 1979),
J Kountouras, and
S McKavanagh, and
M Burmicky, and
B H Billing
May 1979,
The Journal of laboratory and clinical medicine,
J Kountouras, and
S McKavanagh, and
M Burmicky, and
B H Billing
September 1989,
Gut,
J Kountouras, and
S McKavanagh, and
M Burmicky, and
B H Billing
October 1998,
The Journal of toxicological sciences,
J Kountouras, and
S McKavanagh, and
M Burmicky, and
B H Billing
January 1984,
Hepatology (Baltimore, Md.),
J Kountouras, and
S McKavanagh, and
M Burmicky, and
B H Billing
January 1996,
Journal of applied toxicology : JAT,
J Kountouras, and
S McKavanagh, and
M Burmicky, and
B H Billing
January 1971,
Experientia,
J Kountouras, and
S McKavanagh, and
M Burmicky, and
B H Billing
January 1986,
Journal of hepatology,
J Kountouras, and
S McKavanagh, and
M Burmicky, and
B H Billing
December 1963,
Gastroenterology,
J Kountouras, and
S McKavanagh, and
M Burmicky, and
B H Billing
January 1971,
Naunyn-Schmiedebergs Archiv fur Pharmakologie,
