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Alterations in the phospholipid component of membranes were studied in acute myocardial ischemia with respect to sarcoplasmic reticulum (SR) and mitochondria (Mt) in the canine heart and compared with changes in the phospholipid composition of intact membrane treated with exogenous phospholipases (PLases) A2 and C, in order to examine the mechanism of ischemic degradation. As early as 30 min after coronary ligation, the total phospholipid content of SR and Mt decreased significantly, 16.0% and 5.6%, respectively. The patterns of SR and Mt phospholipids from the ischemic myocardia did not differ on the chromatograms from those of the non-ischemic myocardia, and no significant increases in lysophospholipids were found for up to 3 hrs. Among the components of phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE) decreased mainly during ischemia, and depletion of PC exceeded that of PE in SR. PLase C hydrolysed phospholipids yielded no lysophospholipids, compared to the production of a large amount of lysophospholipids by PLase A2. It was concluded that degradation of membrane phospholipids occurs in the early stage of myocardial ischemia mainly in PC and PE, which are the major components of membrane phospholipids. This may be an expression of irreversible changes, and the activation of PLase C was considered to play an important role in their degradation.
T Yanagishita, and
N Konno, and
E Geshi, and
T Katagiri
October 1983,
Lipids,
T Yanagishita, and
N Konno, and
E Geshi, and
T Katagiri
March 1980,
Sheng li ke xue jin zhan [Progress in physiology],
T Yanagishita, and
N Konno, and
E Geshi, and
T Katagiri
January 1986,
The Canadian journal of cardiology,
T Yanagishita, and
N Konno, and
E Geshi, and
T Katagiri
April 2005,
The Journal of thoracic and cardiovascular surgery,
T Yanagishita, and
N Konno, and
E Geshi, and
T Katagiri
March 1987,
Japanese heart journal,
T Yanagishita, and
N Konno, and
E Geshi, and
T Katagiri
April 2000,
Journal of cardiovascular pharmacology and therapeutics,
T Yanagishita, and
N Konno, and
E Geshi, and
T Katagiri
January 1989,
Molecular and cellular biochemistry,
T Yanagishita, and
N Konno, and
E Geshi, and
T Katagiri
January 1975,
Recent advances in studies on cardiac structure and metabolism,
T Yanagishita, and
N Konno, and
E Geshi, and
T Katagiri
January 2022,
Ideggyogyaszati szemle,
T Yanagishita, and
N Konno, and
E Geshi, and
T Katagiri
January 2006,
Medicina,
