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The conversion of testosterone to estradiol by aromatase and to dihydrotestosterone by 5 alpha-reductase was measured in the medial basal hypothalamus of starved and control male rats. Activities of both enzymes were significantly reduced in starved animals. Aromatase activity was 18.2 +/- 2.3 versus 29.8 +/- 5.7 fmol E2/mg protein/90 min (mean +/- SEM, P less than 0.02) and 5 alpha-reductase was 4.95 +/- 0.35 versus 5.96 +/- 0.30 pmol DHT/mg protein/90 min (P less than 0.02) for starved and control animals respectively. The results indicate that hypothalamic metabolism of testosterone is decreased during starvation. Therefore the increased sensitivity of the T-LH feedback described earlier in starved rats [4] cannot be explained by changes in central testosterone metabolism.
M Seidl, and
K M Pirke
August 1975,
Journal of steroid biochemistry,
M Seidl, and
K M Pirke
January 1974,
Problemy endokrinologii,
M Seidl, and
K M Pirke
February 1990,
Endocrinology,
M Seidl, and
K M Pirke
January 1983,
Neuroendocrinology,
M Seidl, and
K M Pirke
January 1993,
Peptides,
M Seidl, and
K M Pirke
April 1976,
Calcified tissue research,
M Seidl, and
K M Pirke
January 1979,
Experientia,
M Seidl, and
K M Pirke
March 1990,
Neuroendocrinology,
M Seidl, and
K M Pirke
January 1989,
Endocrinology,
M Seidl, and
K M Pirke
January 1973,
Neuroendocrinology,
