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Acid glycosaminoglycans (AGAG, mucopolysaccharides) are major constituents of the extracellular matrix. They play a role in filtration and permeability processes, isolation and scaffolding. In childhood no circadian rhythms have been reported up to now. We examined 11 children testing the parameters of: urine volume, creatinine concentration and -excretion, glycosaminoglycan concentration and -excretion, the glycosaminoglycan/creatinine ratio, chondroitin 4 sulfate (Ch4S) in % of total AGAG, Ch4S in mg/2 hrs, heparan sulfate (HS) in % of total AGAG and HS in mg/2 hrs. The biorhythmicity of these data were processed by the cosinor system. We found significant circadian rhythmus for urine volume (acrophase at 1704 hrs, p = 0.05), creatinine concentration (acrophase at 0512 hrs, p = 0.01) and glycosaminoglycan concentration (acrophase at 0358 hrs, p = 0.005). The data presented can form the physiological basis for studies of biorhythmicity in several pathological states as e.g. diabetes and mucopolysaccaridoses.
H Howanietz, and
S Kircher, and
E Schober, and
W Marktl, and
N Klammer, and
M Gruska, and
G Lubec
March 1999,
Archives of disease in childhood,
H Howanietz, and
S Kircher, and
E Schober, and
W Marktl, and
N Klammer, and
M Gruska, and
G Lubec
January 2000,
Archives of disease in childhood,
H Howanietz, and
S Kircher, and
E Schober, and
W Marktl, and
N Klammer, and
M Gruska, and
G Lubec
June 1992,
Clinical chemistry,
H Howanietz, and
S Kircher, and
E Schober, and
W Marktl, and
N Klammer, and
M Gruska, and
G Lubec
June 1996,
Scandinavian journal of urology and nephrology,
H Howanietz, and
S Kircher, and
E Schober, and
W Marktl, and
N Klammer, and
M Gruska, and
G Lubec
January 1972,
Acta paediatrica Academiae Scientiarum Hungaricae,
H Howanietz, and
S Kircher, and
E Schober, and
W Marktl, and
N Klammer, and
M Gruska, and
G Lubec
August 1982,
Nihon Jinzo Gakkai shi,
H Howanietz, and
S Kircher, and
E Schober, and
W Marktl, and
N Klammer, and
M Gruska, and
G Lubec
May 1971,
Acta paediatrica Scandinavica,
H Howanietz, and
S Kircher, and
E Schober, and
W Marktl, and
N Klammer, and
M Gruska, and
G Lubec
June 1986,
JAMA,
H Howanietz, and
S Kircher, and
E Schober, and
W Marktl, and
N Klammer, and
M Gruska, and
G Lubec
January 1993,
International urology and nephrology,
H Howanietz, and
S Kircher, and
E Schober, and
W Marktl, and
N Klammer, and
M Gruska, and
G Lubec
January 1973,
Zeitschrift fur Kinderheilkunde,
