Malignant tumor is a class of diseases with extremely poor prognosis. Current treatment methods mainly include surgical resection, radiotherapy, chemotherapy, immunotherapy, target-therapy, endocrine therapy, and traditional Chinese medicine. For solid malignant tumors, surgical resection is one of the most effective methods. This review proposes a new concept of "target-territory resection" by summarizing a large amount of clinical experience, which can better standardize the implementation of malignant tumor surgery. This technology defines the target-territory area through the principles of differentiation, dynamics and intelligence, thereby determining the optimal operation timing and resection range. According to the "fourstandard surgery" , this operation tries to achieve zero tumor burden, and enables patients to obtain better treatment outcomes.