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The secretory pattern of growth hormone (GH) in 29 to 31 day old immature rats during long-term thiopental anesthesia was studied. Individual GH secretory profiles were determined by sequential blood sampling at 10 min intervals for 6.0 hr starting from about 1.0-1.5 hr after the onset of thiopental administration. EEG was concurrently monitored throughout the experimental period, and the animals were maintained in stable patterns. GH levels in whole blood samples were determined by radioimmunoassay and were subjected to analysis by power spectrum and least-squares methods. The results showed that all 25 immature rats exhibited episodic secretion of GH. Twenty-four of them (96%) showed GH surges occurring with periodicities within the mean +/- 2SD range for the results from unanesthetized, sham-operated animals. The mean periodicity for the 25 animals was 3.25 +/- 0.12 (SE) hr. The results suggest that the rhythmicity of GH secretion observed in the freely-moving condition is maintained during anesthesia.
C Praputpittaya, and
F Kimura
January 1986,
Neuroendocrinology,
C Praputpittaya, and
F Kimura
September 1970,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
C Praputpittaya, and
F Kimura
June 1983,
The Journal of physiology,
C Praputpittaya, and
F Kimura
March 1988,
Regulatory peptides,
C Praputpittaya, and
F Kimura
June 1984,
Nihon Naibunpi Gakkai zasshi,
C Praputpittaya, and
F Kimura
May 1998,
The Journal of clinical endocrinology and metabolism,
C Praputpittaya, and
F Kimura
February 1973,
Postgraduate medical journal,
C Praputpittaya, and
F Kimura
June 1996,
Neuroendocrinology,
C Praputpittaya, and
F Kimura
March 1984,
The Journal of physiology,
C Praputpittaya, and
F Kimura
January 1998,
Pediatric research,
