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Balb c-mice were immunized orally twice within 10 days with a live influenza vaccine (A PR 8/34, H1 N1). Specific antibodies were determined in sera, uterus homogenates and uterus lavage fluids. In all compartments specific antibodies of IgG class were estimated by means of an enzymimmunoassay. Regarding estrogen cyclus of mice the antibody titers were divided into diestrus, proestrus, estrus and metestrus. We have not seen any cyclic changes of antibody titers. The results support the concept of a common immune mucosal system. The continuous antibody titers during genital cyclus are evident for using oral vaccination aiming to induce secretory antibodies in genital tract.
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