This study assessed the coping strategies of Nigerian medical students during the COVID-19 pandemic. We conducted an online descriptive cross-sectional study among medical and dental students attending three of the largest Colleges of Medicine in the Southwestern zone of Nigeria. Our study involved students across the pre-clinical and clinical levels of the three Colleges of Medicine. We selected the respondents through a purposive sampling technique and disseminated questionnaires applied using an online survey platform (Google forms https://forms.gle/19yfEzehJKwsme759). A total of 1010 participants out of 2404 eligible students completed the questionnaires accurately, giving a response rate of 42%. The Brief-COPE questionnaire assessed the participants' coping strategies (approach and avoidant) during the COVID-19 pandemic. We conducted a bivariate analysis using the chi-square test and multiple regression analysis (p< 0.05) to determine the predictors of avoidant coping strategies. Respondents mean age was 21.8±2.9 years, results were presented as Odds Ratios(OR) at 95% confidence intervals(CI). About 95% of respondents employed an approach coping strategy, while the minority(5%) adopted an avoidant coping strategy. Females were three times more likely to employ an avoidant coping strategy (OR=3.32 (95% CI 1.67-6.21) compared to male students. This study reveals that the majority of the respondents employed an approach coping strategy towards the COVID-19 pandemic. Females were more likely to employ an avoidant coping strategy. We recommend gender-specific programs to help medical students cope with the COVID-19 pandemic. No External Funding.