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A double-blind trial was carried out in 37 patients with osteoarthrosis to compare the efficacy and tolerance of 250 mg diflunisal twice daily with that of 400 mg ibuprofen 3-times daily over an 8-week period. Rating scale assessments were made, at the end of a preceding 1-week, wash-out period on placebo and at regular fixed intervals, of weight-bearing pain, night pain, a specific functional activity, and of the duration of inactivity stiffness. Patients' and physician's overall evaluations of response, taking side-effects into account, were made on completion of the study. The data collected indicated that in 30 patients completing the trial both treatments produced similar overall results and, with the exception of weight-bearing pain which appeared to be improved more in the ibuprofen group, diflunisal provided equal therapeutic benefit with fewer side-effects.
B Bresnihan, and
G Hughes, and
W K Essigman
January 1979,
Giornale di clinica medica,
B Bresnihan, and
G Hughes, and
W K Essigman
January 1986,
Clinical therapeutics,
B Bresnihan, and
G Hughes, and
W K Essigman
January 1978,
Current medical research and opinion,
B Bresnihan, and
G Hughes, and
W K Essigman
July 1981,
The New Zealand medical journal,
B Bresnihan, and
G Hughes, and
W K Essigman
August 1991,
Ugeskrift for laeger,
B Bresnihan, and
G Hughes, and
W K Essigman
January 1979,
Current medical research and opinion,
B Bresnihan, and
G Hughes, and
W K Essigman
January 1984,
Pharmatherapeutica,
B Bresnihan, and
G Hughes, and
W K Essigman
January 1983,
MMW, Munchener medizinische Wochenschrift,
B Bresnihan, and
G Hughes, and
W K Essigman
August 1982,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
B Bresnihan, and
G Hughes, and
W K Essigman
February 1980,
Schweizerische medizinische Wochenschrift,
