-transparent.png){kind=logo}
Isozyme 4-4 of rat liver glutathione S-transferase catalyzes the stereoselective addition of glutathione to the oxirane carbon of R-absolute configuration of cis-stilbene oxide, 2, to give 98 +/- 2% of the (1S,2S)-1,2-diphenyl-1-(S-glutathionyl)-2-hydroxyethane product with a turnover number (kc) of 0.22 s-1. The two enantiomers of trans-stilbene oxide, 3, are somewhat poorer substrates for the enzyme. Enantioselective addition of glutathione to 3 proceeds with turnover numbers of 0.12 s-1 and 0.023 s-1 for the (R,R,)- and (S,S)-antipodes, respectively.
Related Publications
P C deSmidt, and
M A McCarrick, and
J N Darnow, and
M Mervic, and
R N Armstrong
February 1983,
Biochemistry,
P C deSmidt, and
M A McCarrick, and
J N Darnow, and
M Mervic, and
R N Armstrong
November 1988,
Archives of biochemistry and biophysics,
P C deSmidt, and
M A McCarrick, and
J N Darnow, and
M Mervic, and
R N Armstrong
October 1984,
Biochemical pharmacology,
P C deSmidt, and
M A McCarrick, and
J N Darnow, and
M Mervic, and
R N Armstrong
May 1981,
The Journal of biological chemistry,
P C deSmidt, and
M A McCarrick, and
J N Darnow, and
M Mervic, and
R N Armstrong
September 1980,
Biochemical and biophysical research communications,
P C deSmidt, and
M A McCarrick, and
J N Darnow, and
M Mervic, and
R N Armstrong
October 1975,
Archives of biochemistry and biophysics,
P C deSmidt, and
M A McCarrick, and
J N Darnow, and
M Mervic, and
R N Armstrong
July 1985,
Biochemical and biophysical research communications,
P C deSmidt, and
M A McCarrick, and
J N Darnow, and
M Mervic, and
R N Armstrong
January 1983,
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry,
P C deSmidt, and
M A McCarrick, and
J N Darnow, and
M Mervic, and
R N Armstrong
January 1986,
Drug metabolism and disposition: the biological fate of chemicals,
P C deSmidt, and
M A McCarrick, and
J N Darnow, and
M Mervic, and
R N Armstrong
December 2012,
Analytical biochemistry,
