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Adult male Wistar rats were exposed to 3.0 Gy local testicular irradiation. Testes of irradiated and non-irradiated rats were examined histologically and flow cytometrically, at several intervals up to 78 days after irradiation. Concentrations of follicle-stimulating hormone, luteinizing hormone and testosterone determined at these intervals were not different from those of controls. The survival of stem cells were measured 11 weeks after irradiation (with doses varying from 1.0 Gy to 6.0 Gy at 0.6 Gy/min) by means of the repopulation index and by the number of haploid cells (spermatids). Correlation between both methods and relation to stem cell survival were discussed. The dose response curves yielded D0 values of stem cell survival of 2.33 +/- 0.06 Gy (repopulation index) and 2.08 +/- 0.08 Gy (number of haploid cells). The D0 value of the rat was not much different from that found in mice. It was concluded that the used parameters can offer insight when studying hormonal substances during irradiation.
M J Van Kroonenburgh, and
W A Van Daal, and
J L Beck, and
H M Vemer, and
R Rolland, and
C J Herman
March 2015,
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases,
M J Van Kroonenburgh, and
W A Van Daal, and
J L Beck, and
H M Vemer, and
R Rolland, and
C J Herman
August 2011,
Zhonghua yi xue za zhi,
M J Van Kroonenburgh, and
W A Van Daal, and
J L Beck, and
H M Vemer, and
R Rolland, and
C J Herman
February 2020,
Zhonghua nan ke xue = National journal of andrology,
M J Van Kroonenburgh, and
W A Van Daal, and
J L Beck, and
H M Vemer, and
R Rolland, and
C J Herman
March 1980,
Radiation research,
M J Van Kroonenburgh, and
W A Van Daal, and
J L Beck, and
H M Vemer, and
R Rolland, and
C J Herman
March 2015,
Environmental toxicology and pharmacology,
M J Van Kroonenburgh, and
W A Van Daal, and
J L Beck, and
H M Vemer, and
R Rolland, and
C J Herman
February 2019,
Molecular and cellular endocrinology,
M J Van Kroonenburgh, and
W A Van Daal, and
J L Beck, and
H M Vemer, and
R Rolland, and
C J Herman
April 2007,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
M J Van Kroonenburgh, and
W A Van Daal, and
J L Beck, and
H M Vemer, and
R Rolland, and
C J Herman
June 1980,
Radiation research,
M J Van Kroonenburgh, and
W A Van Daal, and
J L Beck, and
H M Vemer, and
R Rolland, and
C J Herman
December 1997,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
M J Van Kroonenburgh, and
W A Van Daal, and
J L Beck, and
H M Vemer, and
R Rolland, and
C J Herman
January 1990,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
