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Developmental pattern of ornithine decarboxylase activity, S-adenosylmethionine decarboxylase, and polyamines of rat adrenal glands. 1987

M Ekker, and T L Sourkes

The concentrations of polyamines and the activities of ornithine decarboxylase (ODC) and of S-adenosylmethionine decarboxylase (SAM-DC) were measured in the adrenal glands of rats during development. Adrenal spermine content increases gradually during the first month of life whereas spermidine and putrescine decrease. A low spermidine/spermine ratio is obtained. The developmental pattern of adrenal SAM-DC resembles that of spermine content. The activity of adrenal ornithine decarboxylase increases after birth and attains a peak at 17 days of age. It declines sharply thereafter. Induction of adrenal ODC following the stress of immobilization is already observed in the rat at 4 days of age but the induction caused by maternal deprivation or cold exposure is obtained only at 17 days. The results suggest that the developmental pattern of ODC activity is independent of its responsivity to various stressors.

UI MeSH Term Description Entries
D008297 Male Males
D008426 Maternal Deprivation Prolonged separation of the offspring from the mother. Deprivation, Maternal,Deprivations, Maternal,Maternal Deprivations
D009955 Ornithine Decarboxylase A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine. Ornithine Carboxy-lyase,Carboxy-lyase, Ornithine,Decarboxylase, Ornithine,Ornithine Carboxy lyase
D011073 Polyamines Amine compounds that consist of carbon chains or rings containing two or more primary amino groups. Polyamine
D011700 Putrescine A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine. 1,4-Butanediamine,1,4-Diaminobutane,Tetramethylenediamine,1,4 Butanediamine,1,4 Diaminobutane
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D012149 Restraint, Physical Use of a device for the purpose of controlling movement of all or part of the body. Splinting and casting are FRACTURE FIXATION. Immobilization, Physical,Physical Restraint,Physical Immobilization,Physical Restraints,Restraints, Physical
D002262 Carboxy-Lyases Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1. Carboxy-Lyase,Decarboxylase,Decarboxylases,Carboxy Lyase,Carboxy Lyases
D003080 Cold Temperature An absence of warmth or heat or a temperature notably below an accustomed norm. Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D005260 Female Females

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