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In preparation for an epidemiological investigation of cigarette smoking and cervical neoplasia, we studied methods of measuring cervical exposure to tobacco smoke. The measurement of cotinine in cervical flushes by radioimmunoassay proved to be highly accurate in distinguishing smokers from nonsmokers, achieving 100% sensitivity and 97% specificity. In most subjects, quantitative levels of cervical cotinine and nicotine mirrored recent smoking intensity. Some of the apparent exceptions may have resulted from metabolic/secretory traits of the subjects. If so, the biochemical measurement of smoke constituents in the cervix might prove more valuable for epidemiological studies of cervical neoplasia than data on current smoking behavior collected by interview.
M H Schiffman, and
N J Haley, and
J S Felton, and
A W Andrews, and
R A Kaslow, and
W D Lancaster, and
R J Kurman, and
L A Brinton, and
L B Lannom, and
D Hoffmann
January 1985,
The New England journal of medicine,
M H Schiffman, and
N J Haley, and
J S Felton, and
A W Andrews, and
R A Kaslow, and
W D Lancaster, and
R J Kurman, and
L A Brinton, and
L B Lannom, and
D Hoffmann
January 1992,
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
M H Schiffman, and
N J Haley, and
J S Felton, and
A W Andrews, and
R A Kaslow, and
W D Lancaster, and
R J Kurman, and
L A Brinton, and
L B Lannom, and
D Hoffmann
January 1959,
Mitteilungen aus dem Gebiete der Lebensmittel-untersuchung un Hygiene = Travaux de chimie alimentaire et d'hygiene,
M H Schiffman, and
N J Haley, and
J S Felton, and
A W Andrews, and
R A Kaslow, and
W D Lancaster, and
R J Kurman, and
L A Brinton, and
L B Lannom, and
D Hoffmann
September 1956,
British journal of cancer,
M H Schiffman, and
N J Haley, and
J S Felton, and
A W Andrews, and
R A Kaslow, and
W D Lancaster, and
R J Kurman, and
L A Brinton, and
L B Lannom, and
D Hoffmann
March 1960,
Nature,
M H Schiffman, and
N J Haley, and
J S Felton, and
A W Andrews, and
R A Kaslow, and
W D Lancaster, and
R J Kurman, and
L A Brinton, and
L B Lannom, and
D Hoffmann
May 1993,
Annals of the New York Academy of Sciences,
M H Schiffman, and
N J Haley, and
J S Felton, and
A W Andrews, and
R A Kaslow, and
W D Lancaster, and
R J Kurman, and
L A Brinton, and
L B Lannom, and
D Hoffmann
January 1985,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
M H Schiffman, and
N J Haley, and
J S Felton, and
A W Andrews, and
R A Kaslow, and
W D Lancaster, and
R J Kurman, and
L A Brinton, and
L B Lannom, and
D Hoffmann
October 2012,
International journal of clinical oncology,
M H Schiffman, and
N J Haley, and
J S Felton, and
A W Andrews, and
R A Kaslow, and
W D Lancaster, and
R J Kurman, and
L A Brinton, and
L B Lannom, and
D Hoffmann
February 1992,
American journal of epidemiology,
M H Schiffman, and
N J Haley, and
J S Felton, and
A W Andrews, and
R A Kaslow, and
W D Lancaster, and
R J Kurman, and
L A Brinton, and
L B Lannom, and
D Hoffmann
February 1993,
The Journal of nutrition,
