Biomaterial Database

Effects of tethering on regional spinal cord blood flow and sensory-evoked potentials in growing cats. 1987

J K Kang, and M C Kim, and D S Kim, and J U Song

The spinal cords of 2-week-old kittens were tethered by fixing the end of the filum terminale to the lower sacrum, to study the effects of tethering and untethering on regional spinal cord blood flow (rSCBF), sensory-evoked potentials (SEPs) and clinical features. Progressive sensorimotor deficits and incontinence were observed in all the tethered cats. Cord tethering induced a reduction of rSCBF in the distal spinal cord close to the tethering (L3) by 32% of the normal flow 2 weeks after tethering and by 67% 10 weeks after tethering. Untethering of the cord resulted in an increase of rSCBF, restoring it to the normal level in the group untethered 2 weeks after tethering, but rSCBF did not increase in the group untethered 8 weeks after tethering. The changes in SEPs were observed whenever rSCBF was below 14 ml/100 g per minute. Suppression of the early components of SEPs was observed 2 weeks after tethering and the components were progressively altered in amplitude and latency during the experimental period. It is assumed that early untethering can improve the spinal cord blood flow as well as the function of the cord.

UI	MeSH Term	Description	Entries
D012039	Regional Blood Flow	The flow of BLOOD through or around an organ or region of the body.	Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005073	Evoked Potentials, Somatosensory	The electric response evoked in the CEREBRAL CORTEX by stimulation along AFFERENT PATHWAYS from PERIPHERAL NERVES to CEREBRUM.	Somatosensory Evoked Potentials,Evoked Potential, Somatosensory,Somatosensory Evoked Potential
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013116	Spinal Cord	A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.	Coccygeal Cord,Conus Medullaris,Conus Terminalis,Lumbar Cord,Medulla Spinalis,Myelon,Sacral Cord,Thoracic Cord,Coccygeal Cords,Conus Medullari,Conus Terminali,Cord, Coccygeal,Cord, Lumbar,Cord, Sacral,Cord, Spinal,Cord, Thoracic,Cords, Coccygeal,Cords, Lumbar,Cords, Sacral,Cords, Spinal,Cords, Thoracic,Lumbar Cords,Medulla Spinali,Medullari, Conus,Medullaris, Conus,Myelons,Sacral Cords,Spinal Cords,Spinali, Medulla,Spinalis, Medulla,Terminali, Conus,Terminalis, Conus,Thoracic Cords
D013118	Spinal Cord Diseases	Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.	Myelopathy,Spinal Cord Disorders,Myelopathies,Spinal Cord Disease,Spinal Cord Disorder