Biomaterial Database

Clonal hematopoiesis, inflammation, and cardiovascular disorders: a mitochondrial connection. 2022

Francesco Pileri, and Gioacchino Natoli

Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milano, Italy. Electronic address: francesco.pileri@ieo.it.

Mutations in two antagonistic regulators of DNA methylation, DNMT3A and TET2, are associated with clonal hematopoiesis and increased risk of cardiovascular disorders. Recently, Cobo et al. traced the mechanistic bases for such links to loss of mitochondrial integrity, cytoplasmic dispersion of mitochondrial DNA, and the subsequent activation of interferon-stimulated genes (ISGs) in macrophages.

UI	MeSH Term	Description	Entries
D007249	Inflammation	A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D009154	Mutation	Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.	Mutations
D002318	Cardiovascular Diseases	Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	Adverse Cardiac Event,Cardiac Events,Major Adverse Cardiac Events,Adverse Cardiac Events,Cardiac Event,Cardiac Event, Adverse,Cardiac Events, Adverse,Cardiovascular Disease,Disease, Cardiovascular,Event, Cardiac
D006410	Hematopoiesis	The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).	Hematopoiesis, Medullary,Haematopoiesis,Medullary Hematopoiesis
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000082182	Clonal Hematopoiesis	Expansion of blood cells arising from mutant HEMATOPOIETIC STEM CELLS often related to aging. Mutations on epigenetic regulator genes are common in clonal hematopoiesis and may be a risk factor for HEMATOLOGIC NEOPLASMS and other cardiovascular diseases. When variant allele fraction is at least 2% and is present in the absence of severe cytopenias it is referred to as clonal hematopoiesis of indeterminate potential (CHIP).	ARCH Age-related Clonal Hematopoiesis,Age-related Clonal Hematopoiesis,CCUS Clonal Cytopenia of Undetermined Significance,CHIP Clonal Hematopoiesis of Indeterminate Potential,Clonal Cytopenia of Undetermined Significance,Clonal Hematopoiesis of Indeterminate Potential,ICUS Idiopathic Cytopenias of Undetermined Significance,Idiopathic Cytopenias of Undetermined Significance,ARCH Age related Clonal Hematopoiesis,Age related Clonal Hematopoiesis,Clonal Hematopoiesis, Age-related,Hematopoiesis, Age-related Clonal,Hematopoiesis, Clonal