BIOMAT Database Logo BIOMAT Database Logo

Antitumor activity and lethal toxicity of chemically synthesized tetraacetyl-2-keto-3-deoxyoctonic acid-(alpha 2---6)-D-glucosamine analogues of lipid A. 1987

T Shimizu, and S Akiyama, and T Masuzawa, and Y Yanagihara, and S Nakamoto, and K Achiwa

UI MeSH Term Description Entries
D008050 Lipid A Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties.
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D002286 Carcinoma, Ehrlich Tumor A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms. Ehrlich Ascites Tumor,Ascites Tumor, Ehrlich,Ehrlich Tumor Carcinoma,Tumor, Ehrlich Ascites
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy
D013400 Sugar Acids MONOSACCHARIDES and other sugars that contain one or more carboxylic acid moieties. Acids, Sugar
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

T Shimizu, and S Akiyama, and T Masuzawa, and Y Yanagihara, and S Nakamoto, and K Achiwa
Biological activity of chemically synthesized core sugar linked lipid A analog, heptose-(alpha 1----5)-2-keto-3-deoxyoctonic acid-(alpha 2----6)-2,3-diacyloxyacylglucosamine-4-phosphate.
February 1992, International journal of immunopharmacology,
T Shimizu, and S Akiyama, and T Masuzawa, and Y Yanagihara, and S Nakamoto, and K Achiwa
Synthesis of biologically active tetraacetyl-3-deoxy-D-manno-2-octulosonic acid(KDO)-(alpha 2----6)-D-glucosamine analogs of lipid A.
May 1986, Chemical & pharmaceutical bulletin,
T Shimizu, and S Akiyama, and T Masuzawa, and Y Yanagihara, and S Nakamoto, and K Achiwa
Immunopharmacological activities of 2-keto-3-deoxyoctonic acid-(alpha 2----6)-linked 4-O-phosphono-D-glucosamine derivatives carrying N- and 3-O-acyl substituents.
June 1989, Infection and immunity,
T Shimizu, and S Akiyama, and T Masuzawa, and Y Yanagihara, and S Nakamoto, and K Achiwa
Antitumor activity, mitogenicity, and lethal toxicity of chemically synthesized monosaccharide analogs of lipid A.
July 1988, Journal of pharmacobio-dynamics,
T Shimizu, and S Akiyama, and T Masuzawa, and Y Yanagihara, and S Nakamoto, and K Achiwa
Lipid A and related compounds. XVI. Synthesis of biologically active tetraacetyl-3-deoxy-D-manno-2-octulosonic acid (KDO)-(alpha 2----6)-D-glucosamine-4-phosphates, novel analogs of the nonreducing sugar moiety of lipid A.
November 1987, Chemical & pharmaceutical bulletin,
T Shimizu, and S Akiyama, and T Masuzawa, and Y Yanagihara, and S Nakamoto, and K Achiwa
Antitumor activity and toxicity of methyl 6-[3-(2-chloroethyl)- 3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside in experimental animals.
October 1984, Gan,
T Shimizu, and S Akiyama, and T Masuzawa, and Y Yanagihara, and S Nakamoto, and K Achiwa
Biological activities of chemically synthesized N-acetylneuraminic acid-(alpha 2----6)-monosaccharide analogs of lipid A.
February 1988, FEBS letters,
T Shimizu, and S Akiyama, and T Masuzawa, and Y Yanagihara, and S Nakamoto, and K Achiwa
Gas chromatographic determination of (phosphorylated) 2-keto-3-deoxyoctonic acid, heptoses and glucosamine in bacterial lipopolysaccharides after treatment with hydrofluoric acid, methanolysis and trifluoroacetylation.
January 1989, Journal of chromatography,
T Shimizu, and S Akiyama, and T Masuzawa, and Y Yanagihara, and S Nakamoto, and K Achiwa
3-Keto-6(beta)-hydroxycholanic acid and 3 (alpha)-hydroxy-6-ketocholanic acid.
September 1946, Journal of the American Chemical Society,
T Shimizu, and S Akiyama, and T Masuzawa, and Y Yanagihara, and S Nakamoto, and K Achiwa
Biological activities of chemically synthesized derivatives of lipid A: tetraacetyl-monosaccharides linked to 2,3-acyloxyacylglucosamine-4-phosphate.
September 1989, Chemical & pharmaceutical bulletin,
Copied contents to your clipboard!