Interference by an IgM paraprotein in the bromcresol green method for determination of serum albumin.
1987
R G Reed
UI
MeSH Term
Description
Entries
D007075
Immunoglobulin M
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin.
Abnormal immunoglobulins synthesized by atypical cells of the MONONUCLEAR PHAGOCYTE SYSTEM. Paraproteins containing only light chains lead to Bence Jones paraproteinemia, while the presence of only atypical heavy chains leads to heavy chain disease. Most of the paraproteins show themselves as an M-component (monoclonal gammopathy) in electrophoresis. Diclonal and polyclonal paraproteins are much less frequently encountered.
Paraprotein
D001961
Bromcresol Green
An indicator and reagent. It has been used in serum albumin determinations and as a pH indicator.