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A new reagent strip for the determination of leukocytes in urine (LEUKOSTIX; Ames) is described. The test is based on the esterase activity in leukocytes as a marker. Upon contact between the reagent matrix and a urine containing leukocytes, an amino acid ester is hydrolyzed by the esterase to its corresponding alcohol. The free alcohol then couples with a diazonium salt to produce a purple azo dye. The relative concentration of leukocytes in the urine is obtained by visually comparing the strip reaction with a color chart. Performance of the strip was evaluated in a clinical study involving eight different sites and 867 urine specimens. The comparison method was sediment microscopy; specimens containing five cells or more per high-power field were considered to be positive. Sensitivity was 76.3%, specificity 80.8%. Performance was comparable with that of the CHEMSTRIP LN (Boehringer-Mannheim Diagnostics, Inc.) leukocyte test, which we evaluated concurrently.
A C Skjold, and
L R Stover, and
J H Pendergrass, and
P F Corey, and
J A Cattell, and
A E Burkhardt, and
M P Farinelli, and
R J Tyhach, and
J P Albarella, and
R W Trimmer
October 1962,
Technical bulletin of the Registry of Medical Technologists. American Society of Clinical Pathologists. Registry of Medical Technologists,
A C Skjold, and
L R Stover, and
J H Pendergrass, and
P F Corey, and
J A Cattell, and
A E Burkhardt, and
M P Farinelli, and
R J Tyhach, and
J P Albarella, and
R W Trimmer
January 1992,
Hinyokika kiyo. Acta urologica Japonica,
A C Skjold, and
L R Stover, and
J H Pendergrass, and
P F Corey, and
J A Cattell, and
A E Burkhardt, and
M P Farinelli, and
R J Tyhach, and
J P Albarella, and
R W Trimmer
December 1999,
Clinical chemistry,
A C Skjold, and
L R Stover, and
J H Pendergrass, and
P F Corey, and
J A Cattell, and
A E Burkhardt, and
M P Farinelli, and
R J Tyhach, and
J P Albarella, and
R W Trimmer
January 1997,
La Pediatria medica e chirurgica : Medical and surgical pediatrics,
A C Skjold, and
L R Stover, and
J H Pendergrass, and
P F Corey, and
J A Cattell, and
A E Burkhardt, and
M P Farinelli, and
R J Tyhach, and
J P Albarella, and
R W Trimmer
October 1984,
Journal of clinical microbiology,
A C Skjold, and
L R Stover, and
J H Pendergrass, and
P F Corey, and
J A Cattell, and
A E Burkhardt, and
M P Farinelli, and
R J Tyhach, and
J P Albarella, and
R W Trimmer
December 1964,
The Journal of urology,
A C Skjold, and
L R Stover, and
J H Pendergrass, and
P F Corey, and
J A Cattell, and
A E Burkhardt, and
M P Farinelli, and
R J Tyhach, and
J P Albarella, and
R W Trimmer
February 1987,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
A C Skjold, and
L R Stover, and
J H Pendergrass, and
P F Corey, and
J A Cattell, and
A E Burkhardt, and
M P Farinelli, and
R J Tyhach, and
J P Albarella, and
R W Trimmer
July 1974,
Lancet (London, England),
A C Skjold, and
L R Stover, and
J H Pendergrass, and
P F Corey, and
J A Cattell, and
A E Burkhardt, and
M P Farinelli, and
R J Tyhach, and
J P Albarella, and
R W Trimmer
June 1974,
Lancet (London, England),
A C Skjold, and
L R Stover, and
J H Pendergrass, and
P F Corey, and
J A Cattell, and
A E Burkhardt, and
M P Farinelli, and
R J Tyhach, and
J P Albarella, and
R W Trimmer
February 1971,
Drug and therapeutics bulletin,
